-
Something wrong with this record ?
Tissue mRNA for S100A4, S100A6, S100A8, S100A9, S100A11 and S100P Proteins in Colorectal Neoplasia: A Pilot Study
E. Peterova, J. Bures, P. Moravkova, D. Kohoutova
Language English Country Switzerland
Document type Journal Article
Grant support
academic project PROGRES Q40-15
Univerzita Karlova v Praze
NLK
Directory of Open Access Journals
from 1997
Free Medical Journals
from 1997
PubMed Central
from 2001
Europe PubMed Central
from 2001
ProQuest Central
from 1997-01-01
Open Access Digital Library
from 1997-01-01
Medline Complete (EBSCOhost)
from 2009-03-01
Health & Medicine (ProQuest)
from 1997-01-01
- MeSH
- Adenoma genetics metabolism pathology MeSH
- Calgranulin A genetics metabolism MeSH
- Calgranulin B genetics metabolism MeSH
- Colorectal Neoplasms genetics metabolism pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger genetics metabolism MeSH
- Biomarkers, Tumor genetics metabolism MeSH
- Neoplasm Proteins genetics metabolism MeSH
- Follow-Up Studies MeSH
- Pilot Projects MeSH
- Prognosis MeSH
- S100 Calcium Binding Protein A6 genetics metabolism MeSH
- Cell Cycle Proteins genetics metabolism MeSH
- S100 Proteins genetics metabolism MeSH
- Calcium-Binding Proteins genetics metabolism MeSH
- S100 Calcium-Binding Protein A4 genetics metabolism MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
S100 proteins are involved in the pathogenesis of sporadic colorectal carcinoma through different mechanisms. The aim of our study was to assess tissue mRNA encoding S100 proteins in patients with non-advanced and advanced colorectal adenoma. Mucosal biopsies were taken from the caecum, transverse colon and rectum during diagnostic and/or therapeutic colonoscopy. Another biopsy was obtained from adenomatous tissue in the advanced adenoma group. The tissue mRNA for each S100 protein (S100A4, S100A6, S100A8, S100A9, S100A11 and S100P) was investigated. Eighteen biopsies were obtained from the healthy mucosa in controls and the non-advanced adenoma group (six individuals in each group) and thirty biopsies in the advanced adenoma group (ten patients). Nine biopsies were obtained from advanced adenoma tissue (9/10 patients). Significant differences in mRNA investigated in the healthy mucosa were identified between (1) controls and the advanced adenoma group for S100A6 (p = 0.012), (2) controls and the non-advanced adenoma group for S100A8 (p = 0.033) and (3) controls and the advanced adenoma group for S100A11 (p = 0.005). In the advanced adenoma group, differences between the healthy mucosa and adenomatous tissue were found in S100A6 (p = 0.002), S100A8 (p = 0.002), S100A9 (p = 0.021) and S100A11 (p = 0.029). Abnormal mRNA expression for different S100 proteins was identified in the pathological adenomatous tissue as well as in the morphologically normal large intestinal mucosa.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21019445
- 003
- CZ-PrNML
- 005
- 20211111100736.0
- 007
- ta
- 008
- 210728s2021 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/molecules26020402 $2 doi
- 035 __
- $a (PubMed)33466593
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Peterova, Eva $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove, University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic $u Department of Medical Biochemistry, Charles University, Faculty of Medicine in Hradec Kralove, Simkova 870, 500 01 Hradec Kralove, Czech Republic
- 245 10
- $a Tissue mRNA for S100A4, S100A6, S100A8, S100A9, S100A11 and S100P Proteins in Colorectal Neoplasia: A Pilot Study / $c E. Peterova, J. Bures, P. Moravkova, D. Kohoutova
- 520 9_
- $a S100 proteins are involved in the pathogenesis of sporadic colorectal carcinoma through different mechanisms. The aim of our study was to assess tissue mRNA encoding S100 proteins in patients with non-advanced and advanced colorectal adenoma. Mucosal biopsies were taken from the caecum, transverse colon and rectum during diagnostic and/or therapeutic colonoscopy. Another biopsy was obtained from adenomatous tissue in the advanced adenoma group. The tissue mRNA for each S100 protein (S100A4, S100A6, S100A8, S100A9, S100A11 and S100P) was investigated. Eighteen biopsies were obtained from the healthy mucosa in controls and the non-advanced adenoma group (six individuals in each group) and thirty biopsies in the advanced adenoma group (ten patients). Nine biopsies were obtained from advanced adenoma tissue (9/10 patients). Significant differences in mRNA investigated in the healthy mucosa were identified between (1) controls and the advanced adenoma group for S100A6 (p = 0.012), (2) controls and the non-advanced adenoma group for S100A8 (p = 0.033) and (3) controls and the advanced adenoma group for S100A11 (p = 0.005). In the advanced adenoma group, differences between the healthy mucosa and adenomatous tissue were found in S100A6 (p = 0.002), S100A8 (p = 0.002), S100A9 (p = 0.021) and S100A11 (p = 0.029). Abnormal mRNA expression for different S100 proteins was identified in the pathological adenomatous tissue as well as in the morphologically normal large intestinal mucosa.
- 650 _2
- $a adenom $x genetika $x metabolismus $x patologie $7 D000236
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a nádorové biomarkery $x genetika $x metabolismus $7 D014408
- 650 _2
- $a proteiny vázající vápník $x genetika $x metabolismus $7 D002135
- 650 _2
- $a kalgranulin A $x genetika $x metabolismus $7 D040501
- 650 _2
- $a kalgranulin B $x genetika $x metabolismus $7 D040502
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a proteiny buněčného cyklu $x genetika $x metabolismus $7 D018797
- 650 _2
- $a kolorektální nádory $x genetika $x metabolismus $x patologie $7 D015179
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a nádorové proteiny $x genetika $x metabolismus $7 D009363
- 650 _2
- $a pilotní projekty $7 D010865
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a messenger RNA $x genetika $x metabolismus $7 D012333
- 650 _2
- $a protein S100A6 $x genetika $x metabolismus $7 D000075383
- 650 _2
- $a S100 kalcium vázající protein A4 $x genetika $x metabolismus $7 D000071999
- 650 _2
- $a proteiny S100 $x genetika $x metabolismus $7 D009418
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Bures, Jan $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove, University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
- 700 1_
- $a Morávková, Paula $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove, University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic $7 xx0266480
- 700 1_
- $a Kohoutova, Darina $u 2nd Department of Internal Medicine-Gastroenterology, Charles University, Faculty of Medicine in Hradec Kralove, University Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic $u The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK
- 773 0_
- $w MED00180394 $t Molecules (Basel, Switzerland) $x 1420-3049 $g Roč. 26, č. 2 (2021)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33466593 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210728 $b ABA008
- 991 __
- $a 20211111100735 $b ABA008
- 999 __
- $a ok $b bmc $g 1690298 $s 1139891
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 26 $c 2 $e 20210114 $i 1420-3049 $m Molecules $n Molecules $x MED00180394
- GRA __
- $a academic project PROGRES Q40-15 $p Univerzita Karlova v Praze
- LZP __
- $a Pubmed-20210728
