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Low-level fat fraction quantification at 3 T: comparative study of different tools for water-fat reconstruction and MR spectroscopy

R. Kořínek, M. Gajdošík, S. Trattnig, Z. Starčuk, M. Krššák

. 2020 ; 33 (4) : 455-468. [pub] 20200124

Jazyk angličtina Země Německo

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21020312

Grantová podpora
CZ.1.05/2.1.00/01.0017 Ministerstvo Školství, Mládeže a Tělovýchovy
LO1212 Ministerstvo Školství, Mládeže a Tělovýchovy
7AMB18AT023 Ministerstvo Školství, Mládeže a Tělovýchovy
8J18AT023 Ministerstvo Školství, Mládeže a Tělovýchovy
AKTION AUT-CZE # 74p6 Ministerstvo Školství, Mládeže a Tělovýchovy
MSM100651801 Akademie Věd České Republiky

OBJECTIVES: Chemical Shift Encoded Magnetic Resonance Imaging (CSE-MRI)-based quantification of low-level (< 5% of proton density fat fraction-PDFF) fat infiltration requires highly accurate data reconstruction for the assessment of hepatic or pancreatic fat accumulation in diagnostics and biomedical research. MATERIALS AND METHODS: We compare three software tools available for water/fat image reconstruction and PDFF quantification with MRS as the reference method. Based on the algorithm exploited in the tested software, the accuracy of fat fraction quantification varies. We evaluate them in phantom and in vivo MRS and MRI measurements. RESULTS: The signal model of Intralipid 20% emulsion used for phantoms was established for 3 T and 9.4 T fields. In all cases, we noticed a high coefficient of determination (R-squared) between MRS and MRI-PDFF measurements: in phantoms <0.9924-0.9990>; and in vivo <0.8069-0.9552>. Bland-Altman analysis was applied to phantom and in vivo measurements. DISCUSSION: Multi-echo MRI in combination with an advanced algorithm including multi-peak spectrum modeling appears as a valuable and accurate method for low-level PDFF quantification over large FOV in high resolution, and is much faster than MRS methods. The graph-cut algorithm (GC) showed the fewest water/fat swaps in the PDFF maps, and hence stands out as the most robust method of those tested.

Citace poskytuje Crossref.org

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