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Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

AS. Oliva Chávez, X. Wang, L. Marnin, NK. Archer, HL. Hammond, EEM. Carroll, DK. Shaw, BG. Tully, AD. Buskirk, SL. Ford, LR. Butler, P. Shahi, K. Morozova, CC. Clement, L. Lawres, AJO. Neal, CB. Mamoun, KL. Mason, BE. Hobbs, GA. Scoles, EM....

. 2021 ; 12 (1) : 3696. [pub] 20210617

Language English Country Great Britain

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.

Persistent link   https://www.medvik.cz/link/bmc21025565

Grant support
F31 AI152215 NIAID NIH HHS - United States
R01 AI116620 NIAID NIH HHS - United States
R01 AI123129 NIAID NIH HHS - United States
F31 AI138440 NIAID NIH HHS - United States
R01 AI116523 NIAID NIH HHS - United States
R01 AI134696 NIAID NIH HHS - United States
R01 AI049424 NIAID NIH HHS - United States
R01 HL141611 NHLBI NIH HHS - United States
P01 AI138949 NIAID NIH HHS - United States

Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.

Center for Drug Evaluation and Research Office of Pharmaceutical Quality Office of Process and Facilities Division of Microbiology Assessment Microbiology Assessment Branch 3 U S Food and Drug Administration Silver Spring MD USA

Center for Vaccine Development and Global Health University of Maryland School of Medicine Baltimore MD USA

Centers for Disease Control and Prevention Atlanta GA USA

Department of Biological Sciences Old Dominion University Norfolk VA USA

Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA

Department of Entomology Texas A and M University College Station TX USA

Department of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH USA

Department of Medicine University of Maryland School of Medicine Baltimore MD USA

Department of Microbiology and Immunology Albert Einstein College of Medicine Bronx NY USA

Department of Microbiology and Immunology University of Maryland School of Medicine Baltimore MD USA

Department of Pathology Albert Einstein College of Medicine Bronx NY USA

Department of Pediatrics University of Maryland School of Medicine Baltimore MD USA

Department of Radiation Oncology and Physiology and Biophysics Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA

Department of Veterinary Medicine University of Maryland College Park MD USA

Department of Veterinary Microbiology and Pathology Washington State University Pullman WA USA

Excerpta Medica Doylestown PA USA

Fischell Department of Bioengineering University of Maryland College Park MD USA

Immunology Janssen Research and Development Spring House PA USA

Institute of Parasitology Biology Center of the Czech Academy of Sciences Ceske Budejovice Czech Republic

Section of Infectious Diseases Department of Internal Medicine Yale University School of Medicine New Haven CT USA

USDA ARS Animal Disease Research Unit Washington State University Pullman WA USA

USDA ARS Invasive Insect Biocontrol and Behavior Laboratory Beltsville MD USA

Vector Molecular Biology Section Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health Rockville MD USA

References provided by Crossref.org

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