• Something wrong with this record ?

The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults

J. Laczó, K. Cechova, M. Parizkova, O. Lerch, R. Andel, V. Matoska, V. Kaplan, V. Matuskova, Z. Nedelska, M. Vyhnalek, J. Hort

. 2020 ; 78 (4) : 1473-1492. [pub] -

Language English Country Netherlands

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21026775

BACKGROUND: The apolipoprotein E (APOE) ɛ4 allele is associated with episodic memory and spatial navigation deficits. The brain-derived neurotrophic factor (BDNF) Met allele may further worsen memory impairment in APOEɛ4 carriers but its role in APOEɛ4-related spatial navigation deficits has not been established. OBJECTIVE: We examined influence of APOE and BDNF Val66Met polymorphism combination on spatial navigation and volumes of selected navigation-related brain regions in cognitively unimpaired (CU) older adults and those with amnestic mild cognitive impairment (aMCI). METHODS: 187 participants (aMCI [n = 116] and CU [n = 71]) from the Czech Brain Aging Study were stratified based on APOE and BDNF Val66Met polymorphisms into four groups: ɛ4-/BDNFVal/Val, ɛ4-/BDNFMet, ɛ4+/BDNFVal/Val, and ɛ4+/BDNFMet. The participants underwent comprehensive neuropsychological examination, brain MRI, and spatial navigation testing of egocentric, allocentric, and allocentric delayed navigation in a real-space human analogue of the Morris water maze. RESULTS: Among the aMCI participants, the ɛ4+/BDNFMet group had the least accurate egocentric navigation performance (p < 0.05) and lower verbal memory performance than the ɛ4-/BDNFVal/Val group (p = 0.007). The ɛ4+/BDNFMet group had smaller hippocampal and entorhinal cortical volumes than the ɛ4-/BDNFVal/Val (p≤0.019) and ɛ4-/BDNFMet (p≤0.020) groups. Among the CU participants, the ɛ4+/BDNFMet group had less accurate allocentric and allocentric delayed navigation performance than the ɛ4-/BDNFVal/Val group (p < 0.05). CONCLUSION: The combination of APOEɛ4 and BDNF Met polymorphisms is associated with more pronounced egocentric navigation impairment and atrophy of the medial temporal lobe regions in individuals with aMCI and less accurate allocentric navigation in CU older adults.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21026775
003      
CZ-PrNML
005      
20250709093455.0
007      
ta
008      
211013s2020 ne f 000 0|eng||
009      
AR
024    7_
$a 10.3233/JAD-200615 $2 doi
035    __
$a (PubMed)33325388
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Laczó, Jan $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
245    14
$a The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults / $c J. Laczó, K. Cechova, M. Parizkova, O. Lerch, R. Andel, V. Matoska, V. Kaplan, V. Matuskova, Z. Nedelska, M. Vyhnalek, J. Hort
520    9_
$a BACKGROUND: The apolipoprotein E (APOE) ɛ4 allele is associated with episodic memory and spatial navigation deficits. The brain-derived neurotrophic factor (BDNF) Met allele may further worsen memory impairment in APOEɛ4 carriers but its role in APOEɛ4-related spatial navigation deficits has not been established. OBJECTIVE: We examined influence of APOE and BDNF Val66Met polymorphism combination on spatial navigation and volumes of selected navigation-related brain regions in cognitively unimpaired (CU) older adults and those with amnestic mild cognitive impairment (aMCI). METHODS: 187 participants (aMCI [n = 116] and CU [n = 71]) from the Czech Brain Aging Study were stratified based on APOE and BDNF Val66Met polymorphisms into four groups: ɛ4-/BDNFVal/Val, ɛ4-/BDNFMet, ɛ4+/BDNFVal/Val, and ɛ4+/BDNFMet. The participants underwent comprehensive neuropsychological examination, brain MRI, and spatial navigation testing of egocentric, allocentric, and allocentric delayed navigation in a real-space human analogue of the Morris water maze. RESULTS: Among the aMCI participants, the ɛ4+/BDNFMet group had the least accurate egocentric navigation performance (p < 0.05) and lower verbal memory performance than the ɛ4-/BDNFVal/Val group (p = 0.007). The ɛ4+/BDNFMet group had smaller hippocampal and entorhinal cortical volumes than the ɛ4-/BDNFVal/Val (p≤0.019) and ɛ4-/BDNFMet (p≤0.020) groups. Among the CU participants, the ɛ4+/BDNFMet group had less accurate allocentric and allocentric delayed navigation performance than the ɛ4-/BDNFVal/Val group (p < 0.05). CONCLUSION: The combination of APOEɛ4 and BDNF Met polymorphisms is associated with more pronounced egocentric navigation impairment and atrophy of the medial temporal lobe regions in individuals with aMCI and less accurate allocentric navigation in CU older adults.
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a apolipoprotein E4 $x genetika $7 D053327
650    _2
$a mozkový neurotrofický faktor $x genetika $7 D019208
650    _2
$a kognitivní dysfunkce $x genetika $x patofyziologie $7 D060825
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a polymorfismus genetický $7 D011110
650    _2
$a prostorová navigace $x fyziologie $7 D065854
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Cechova, Katerina $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Parizkova, Martina $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Lerch, Ondřej $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $7 xx0333546
700    1_
$a Andel, Ross $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u School of Aging Studies, University of South Florida, Tampa, FL, USA
700    1_
$a Matoska, Vaclav $u Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, Prague, Czech Republic
700    1_
$a Kaplan, Vojtech $u Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, Prague, Czech Republic
700    1_
$a Matuskova, Veronika $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Nedelska, Zuzana $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Vyhnalek, Martin $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Hort, Jakub $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
773    0_
$w MED00006350 $t Journal of Alzheimer's disease $x 1875-8908 $g Roč. 78, č. 4 (2020), s. 1473-1492
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33325388 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20250709093446 $b ABA008
999    __
$a ok $b bmc $g 1715505 $s 1147282
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 78 $c 4 $d 1473-1492 $e - $i 1875-8908 $m Journal of Alzheimer's disease $n J Alzheimers Dis $x MED00006350
LZP    __
$a Pubmed-20211013

Find record

Citation metrics

Archiving options