-
Je něco špatně v tomto záznamu ?
Is computer-assisted aminoglycoside dosing managed by a pharmacist a safety tool of pharmacotherapy
E. Dvořáčková, P. Pávek, B. Kováčová, J. Rychlíčková, O. Suchopár, M. Hojný, J. D. Tebbens, J. Vlček
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 1991
Free Medical Journals
od 1998
ProQuest Central
od 2005-01-01
Medline Complete (EBSCOhost)
od 2006-01-01
Nursing & Allied Health Database (ProQuest)
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1998
- MeSH
- amikacin aplikace a dávkování MeSH
- aminoglykosidy aplikace a dávkování škodlivé účinky farmakokinetika MeSH
- antibakteriální látky aplikace a dávkování MeSH
- bezpečnost MeSH
- farmaceuti * MeSH
- gentamiciny aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- monitorování léčiv ekonomika metody MeSH
- náklady a analýza nákladů MeSH
- nemoci ledvin chemicky indukované MeSH
- pilotní projekty MeSH
- počítačová farmakoterapie metody MeSH
- prospektivní studie MeSH
- senioři MeSH
- výpočet dávky léku * MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
This pilot prospective study verified the hypothesis that use of computer-assisted therapeutic drug monitoring of aminoglycosides by pharmacists leads to better safety therapeutic outcomes and cost avoidance than only concentration measurement and dose adjustments based on a physician's experience. Two groups of patients were enrolled according to the technique of monitoring. Patients (Group 1, n=52) underwent monitoring by a pharmacist using pharmacokinetic software. In a control group (Group 2, n=11), plasma levels were measured but not interpreted by the pharmacist, only by physicians. No statistically significant differences were found between the groups in factors influenced by therapy. However, the results are not statistically significant but a comparison of the groups showed a clear trend towards safety and cost avoidance, thus supporting therapeutic drug monitoring. Safety limits were achieved in 76 % and 63 % of cases in Groups 1 and 2, respectively. More patients achieved both concentrations (peak and trough) with falling eGFR in Group 1. In present pilot study, the pharmacist improved the care of patients on aminoglycoside therapy. A larger study is needed to demonstrate statistically significantly improved safety and cost avoidance of aminoglycoside therapy monitoring by the pharmacist using pharmacokinetic software.
Department of Clinical Pharmacy Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Clinical Pharmacy Teaching Hospital Plzeň Czech Republic
Department of Pharmacology Faculty of Medicine Charles University Hradec Králové Czech Republic
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Social and Clinical Pharmacy Faculty of Pharmacy Hradec Králové Czech Republic
Drugagency a s Prague Czech Republic
Hospital Pharmacy Institute for Clinical and Experimental Medicine Prague Czech Republic
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21028159
- 003
- CZ-PrNML
- 005
- 20220328133808.0
- 007
- ta
- 008
- 211105s2019 xr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.934329 $2 doi
- 035 __
- $a (PubMed)31755294
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Dvořáčková, Eliška $7 kv2015890922 $u Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Hradec Králové, Czech Republic $u Hospital Pharmacy, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 245 10
- $a Is computer-assisted aminoglycoside dosing managed by a pharmacist a safety tool of pharmacotherapy / $c E. Dvořáčková, P. Pávek, B. Kováčová, J. Rychlíčková, O. Suchopár, M. Hojný, J. D. Tebbens, J. Vlček
- 504 __
- $a Literatura
- 520 9_
- $a This pilot prospective study verified the hypothesis that use of computer-assisted therapeutic drug monitoring of aminoglycosides by pharmacists leads to better safety therapeutic outcomes and cost avoidance than only concentration measurement and dose adjustments based on a physician's experience. Two groups of patients were enrolled according to the technique of monitoring. Patients (Group 1, n=52) underwent monitoring by a pharmacist using pharmacokinetic software. In a control group (Group 2, n=11), plasma levels were measured but not interpreted by the pharmacist, only by physicians. No statistically significant differences were found between the groups in factors influenced by therapy. However, the results are not statistically significant but a comparison of the groups showed a clear trend towards safety and cost avoidance, thus supporting therapeutic drug monitoring. Safety limits were achieved in 76 % and 63 % of cases in Groups 1 and 2, respectively. More patients achieved both concentrations (peak and trough) with falling eGFR in Group 1. In present pilot study, the pharmacist improved the care of patients on aminoglycoside therapy. A larger study is needed to demonstrate statistically significantly improved safety and cost avoidance of aminoglycoside therapy monitoring by the pharmacist using pharmacokinetic software.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a amikacin $x aplikace a dávkování $7 D000583
- 650 _2
- $a aminoglykosidy $x aplikace a dávkování $x škodlivé účinky $x farmakokinetika $7 D000617
- 650 _2
- $a antibakteriální látky $x aplikace a dávkování $7 D000900
- 650 _2
- $a náklady a analýza nákladů $7 D003365
- 650 12
- $a výpočet dávky léku $7 D054796
- 650 _2
- $a monitorování léčiv $x ekonomika $x metody $7 D016903
- 650 _2
- $a počítačová farmakoterapie $x metody $7 D004360
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a gentamiciny $x aplikace a dávkování $7 D005839
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a nemoci ledvin $x chemicky indukované $7 D007674
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a farmaceuti $7 D010595
- 650 _2
- $a pilotní projekty $7 D010865
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a bezpečnost $7 D012449
- 650 _2
- $a výsledek terapie $7 D016896
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Pávek, Petr $7 xx0093070 $u Department of Pharmacology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic
- 700 1_
- $a Kováčová, Barbora $7 xx0244558 $u Department of Clinical Pharmacy, Teaching Hospital, Plzeň, Czech Republic
- 700 1_
- $a Rychlíčková, Jitka $7 xx0230558 $u Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Department of Clinical Pharmacy, Masaryk Memorial Cancer Institute, Brno, Czech Republic
- 700 1_
- $a Suchopár, Ondřej $7 xx0267295 $u Drugagency a.s., Prague, Czech Republic
- 700 1_
- $a Hojný, Michal, $d 1976- $7 xx0104476 $u Hospital Pharmacy, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 700 1_
- $a Tebbens, Jurjen Duintjer $7 _AN084306 $u Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
- 700 1_
- $a Vlček, Jiří, $d 1954- $7 jn20000402562 $u Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, Suppl 1 (2019), s. S87-S96
- 773 0_
- $t 69th Czech-Slovak pharmacological days $g (2019), s. S87-S96 $w MED00208902
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31755294 $y Pubmed
- 910 __
- $a ABA008 $b A 4120 $c 266 $y p $z 0
- 990 __
- $a 20211105 $b ABA008
- 991 __
- $a 20220328133806 $b ABA008
- 999 __
- $a ok $b bmc $g 1728762 $s 1148704
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 68 $c Suppl 1 $d S87-S96 $e 20191122 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- BMC __
- $a 2019 $d S87-S96 $m 69th Czech-Slovak pharmacological days $x MED00208902
- LZP __
- $b NLK118 $a Pubmed-20211105