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Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview
M. Vrijheid, X. Basagaña, JR. Gonzalez, VWV. Jaddoe, G. Jensen, HC. Keun, RRC. McEachan, J. Porcel, V. Siroux, MA. Swertz, C. Thomsen, GM. Aasvang, S. Andrušaitytė, K. Angeli, D. Avraam, F. Ballester, P. Burton, M. Bustamante, M. Casas, L....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 2018
PubMed Central
od 2019
ROAD: Directory of Open Access Scholarly Resources
od 2017
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.
Bettair Cities SL Barcelona Spain
Biodonostia Research Health Institute Donostia San Sebastian Spain
Brunel University London College of Health Medicine and Life Sciences Uxbridge United Kingdom
Cancer Epidemiology Unit Department of Medical Sciences University of Turin Turin Italy
Centre for Environmental Sciences Hasselt University Hasselt Belgium
Centre for Health and Environment Leuven University Leuven Belgium
CHU de Rennes University Rennes Inserm EHESP Irset UMR_S 1085 Rennes France
Department of Biosciences Nottingham Trent University Nottingham United Kingdom
Department of Environmental Health Norwegian Institute of Public Health Oslo Norway
Department of Environmental Sciences Vytautas Magnus University Kaunas Lithuania
Department of Pediatrics Erasmus University Medical Center Rotterdam The Netherlands
Department of Public Health Policy and Systems University of Liverpool Liverpool United Kingdom
Department of Public Health University of Copenhagen Copenhagen Denmark
Department of Social Medicine School of Medicine University of Crete Heraklion Crete Greece
Faculty of Nursing and Chiropody Universitat de València Valencia Spain
Health and Environment Alliance Brussels Belgium
Institut de Recerca Sant Joan de Déu Barcelona Spain
Maternal and Child Health and Development Network 2 Madrid Spain
National Institute for Public Health and the Environment Bilthoven The Netherlands
Population Health Sciences Institute Newcastle University Newcastle United Kingdom
RECETOX Centre Faculty of Science Masaryk University Brno Czech Republic
Spanish Consortium for Research on Epidemiology and Public Health Madrid Spain
The Generation R Study Group Erasmus University Medical Center Rotterdam The Netherlands
Universitat Pompeu Fabra Barcelona Spain
University Grenoble Alpes CNRS INRAE Grenoble INP GAEL Grenoble France
University of Basque Country UPV EHU Basque Country Bilbao Spain
University Rennes Inserm EHESP Irset UMR_S 1085 Rennes France
Citace poskytuje Crossref.org
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