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Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health
A. Mishra, HA. Shaik, RK. Sinha, BR. Shah
Language English Country Switzerland
Document type Journal Article, Review
Grant support
PROFISH (CZ.02.1.01 / 0.0 / 0.0 / 16_019 / 0000869)
University of South Bohemia in České Budějovice
CENAKVA project (LM2018099)
Ministry of Education, Youth and Sports of the Czech Republic
NLK
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- MeSH
- Antiviral Agents chemical synthesis chemistry pharmacology therapeutic use MeSH
- Diterpenes chemical synthesis chemistry pharmacology therapeutic use MeSH
- Immune System drug effects MeSH
- Plants, Medicinal chemistry immunology MeSH
- Humans MeSH
- Virus Diseases drug therapy MeSH
- Health MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C20H30O5) isolated from Andrographis paniculate (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.
References provided by Crossref.org
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