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SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units
J. Benes, M. Jankowski, K. Szułdrzynski, R. Zahorec, M. Lainscak, Z. Ruszkai, M. Podbregar, J. Zatloukal, J. Kletecka, K. Kusza, J. Szrama, E. Ramic, K. Galkova, S. Krbila, J. Valky, J. Ivanic, M. Kurnik, A. Mikó, T. Kiss, B. Hetényi, P. Hegyi,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
Grantová podpora
CZ.02.1.01/0.0/0.0/16_019/0000787
Development of Scientific Fields of Charles University
GINOP-2.3.2-15-2016-00048 STAY ALIVE
Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
K138816
Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-12-01
- MeSH
- COVID-19 * epidemiologie terapie MeSH
- dospělí MeSH
- jednotky intenzivní péče MeSH
- kyslík MeSH
- lidé MeSH
- registrace MeSH
- respirační insuficience * epidemiologie terapie MeSH
- retrospektivní studie MeSH
- SARS-CoV-2 MeSH
- sepse * epidemiologie MeSH
- syndrom dechové tísně * MeSH
- umělé dýchání MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative. We conducted a retrospective, international, multicentre study between March 2020 and February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Eleven centres from six countries provided data from 2139 patients. Patient characteristics were: median 68, [IQR 60-75] years of age; males: 67%; body mass index: 30.1 [27.0-34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p = 0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n = 54). The rest of the patients received non-invasive ventilation (n = 129), high flow nasal oxygen (n = 317), conventional oxygen therapy (n = 122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national-international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.
Anesthesiology and Intensive Medicine Medical School Comenius University Bratislava Slovakia
Biomedical Centre Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Centre for Translational Medicine Semmelweis University Budapest Hungary
Department for Internal Care Medicine General Hospital Celje Celje Slovenia
Department of Anaesthesia and Intensive Therapy University Hospital Nové Zámky Nové Zamky Slovakia
Department of Anaesthesiology and Intensive Care Faculty Hospital Nitra Slovakia
Department of Anaesthesiology and Intensive Therapy Semmelweis University Budapest Hungary
Division for Pancreatic Disorders Heart and Vascular Center Semmelweis University Budapest Hungary
Division of Cardiology General Hospital Murska Sobota Murska Sobota Slovenia
Faculty of Medicine University of Ljubljana Ljubljana Slovenia
Citace poskytuje Crossref.org
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