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Immune dysregulation and pathogenic pathways mediated by common infections in rheumatoid arthritis
S. Salehi, SM. Mahmoudinezhad Dezfouli, H. Azadeh, S. Khosravi
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, přehledy
- MeSH
- infekce virem Epsteina-Barrové * komplikace MeSH
- lidé MeSH
- revmatoidní artritida * komplikace genetika MeSH
- virus Epsteinův-Barrové MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Rheumatoid arthritis (RA) is one of the world's most prevalent inflammatory autoimmune diseases, affecting between 0.4 and 1.3% of the population. The susceptibility to RA appears to be influenced by a complex interaction between a favorable genetic background and the existence of a specific immune reaction against a wide range of environmental variables. Among the known environmental variables, infections are believed to have a significant role in promoting the formation of autoimmune disorders, which are frequently caused by specific microorganisms. Infections have been linked to RA in recent medical studies. In this study, we selected the most prevalent infections associated with RA from the literature and described the data confirming their pathogenic role in RA. Our investigation included Mycobacterium, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Proteus mirabilis, Epstein-Barr virus, parvovirus, and Prevotella copri.
Citace poskytuje Crossref.org
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- $a Salehi, Shima $u Department of Pediatrics Rheumatology, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran
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- $a Rheumatoid arthritis (RA) is one of the world's most prevalent inflammatory autoimmune diseases, affecting between 0.4 and 1.3% of the population. The susceptibility to RA appears to be influenced by a complex interaction between a favorable genetic background and the existence of a specific immune reaction against a wide range of environmental variables. Among the known environmental variables, infections are believed to have a significant role in promoting the formation of autoimmune disorders, which are frequently caused by specific microorganisms. Infections have been linked to RA in recent medical studies. In this study, we selected the most prevalent infections associated with RA from the literature and described the data confirming their pathogenic role in RA. Our investigation included Mycobacterium, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Proteus mirabilis, Epstein-Barr virus, parvovirus, and Prevotella copri.
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- $a Mahmoudinezhad Dezfouli, Seyedeh Mahsa $u Emergency Medicine Management Research Center, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran
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- $a Azadeh, Hossein $u Department of Internal Medicine, Rheumatology Division, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran
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- $a Khosravi, Shaqayeq $u Emergency Medicine Management Research Center, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran. khosravi.sh@iums.ac.ir $1 https://orcid.org/000000015107258X
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