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Use of concomitant proton pump inhibitors, statins or metformin in patients treated with pembrolizumab for metastatic urothelial carcinoma: data from the ARON-2 retrospective study
O. Fiala, S. Buti, H. Takeshita, Y. Okada, F. Massari, GA. Palacios, M. Dionese, S. Scagliarini, T. Büttner, G. Fornarini, ZW. Myint, L. Galli, VC. Souza, R. Pichler, U. De Giorgi, MNG. Quiroga, D. Gilbert, L. Popovic, E. Grande, G. Mammone, R....
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
NLK
PubMed Central
od 1982
ProQuest Central
od 1997-03-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-04-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-03-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-03-01 do Před 1 rokem
- MeSH
- inhibitory protonové pumpy MeSH
- karcinom z přechodných buněk * MeSH
- lidé MeSH
- metformin * terapeutické užití MeSH
- nádory močového měchýře * MeSH
- retrospektivní studie MeSH
- statiny * terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Concomitant medications may potentially affect the outcome of cancer patients. In this sub-analysis of the ARON-2 real-world study (NCT05290038), we aimed to assess the impact of concomitant use of proton pump inhibitors (PPI), statins, or metformin on outcome of patients with metastatic urothelial cancer (mUC) receiving second-line pembrolizumab. METHODS: We collected data from the hospital medical records of patients with mUC treated with pembrolizumab as second-line therapy at 87 institutions from 22 countries. Patients were assessed for overall survival (OS), progression-free survival (PFS), and overall response rate. We carried out a survival analysis by a Cox regression model. RESULTS: A total of 802 patients were eligible for this retrospective study; the median follow-up time was 15.3 months. PPI users compared to non-users showed inferior PFS (4.5 vs. 7.2 months, p = 0.002) and OS (8.7 vs. 14.1 months, p < 0.001). Concomitant PPI use remained a significant predictor of PFS and OS after multivariate Cox analysis. The use of statins or metformin was not associated with response or survival. CONCLUSIONS: Our study results suggest a significant prognostic impact of concomitant PPI use in mUC patients receiving pembrolizumab in the real-world context. The mechanism of this interaction warrants further elucidation.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Centro de Pesquisas Oncológicas CEPON Florianópolis SC Brazil
Centro Oncologico Estatal Dr José Luis Barrera Franco del ISSEMYM Toluca de Lerdo Mexico
Centro Paulista de Oncologia Oncoclinicas Sao Paulo Brazil
Clínica AMO Salvador BA Brazil
Clinica de Oncologia Clion Salvador BA Brazil
Clinica Medica Especializada en Oncologia Medica Guatemala City Guatemala
Clinical Oncology Sociedad de Oncología Y Hematología del Cesar Valledupar Colombia
Clinicas Medicas Especializadas NUCARE Guatemala City Guatemala
Dana Farber Cancer Institute Harvard Medical School Boston MA USA
Department of Biomedical Sciences Humanitas University Pieve Emanuele Milan Italy
Department of Medical Oncology Centre Hospitalier de Jolimont Haine Saint Paul Belgium
Department of Medical Oncology Hospital Ramón Y Cajal Madrid Spain
Department of Medical Oncology Maggiore Della Carità University Hospital 28100 Novara Italy
Department of Medical Oncology MD Anderson Cancer Center Madrid Madrid Spain
Department of Medicine and Surgery University Hospital of Parma Parma Italy
Department of Oncology Candiolo Cancer Institute FPO IRCCS Candiolo Turin Italy
Department of Oncology Hospital Sírio Libanês São Paulo SP Brazil
Department of Oncology IRCCS Humanitas Research Hospital Rozzano Milan Italy
Department of Oncology San Camillo Forlanini Hospital Rome Italy
Department of Urology Medical University of Innsbruck Anichstrasse 35 6020 Innsbruck Austria
Department of Urology Saitama Medical Center Saitama Medical University Saitama Japan
Department of Urology University Hospital Bonn 53127 Bonn Germany
Dipartimento Di Oncologia Medica Fondazione IRCCS Istituto Nazionale Dei Tumori Milan Italy
Fundacion Centro Oncologico de Integracion Regional COIR Mendoza Argentina
Hospital AC Camargo São Paulo SP Brazil
Hospital Angel Roffo Buenos Aires CABA Argentina
Hospital Beneficencia Portuguesa de São Paulo São Paulo SP Brazil
Hospital do Câncer Porto Dias Rede Mater Dei de Saúde Belém PA Brazil
Hospital Erasto Gaertner Curitiba PR Brazil
Hospital Israelita Albert Einstein São Paulo SP Brazil
Hospital Santa Casa de Sao Paulo São Paulo SP Brazil
Hospital São Rafael Oncologia D'Or Salvador BA Brazil
Hospital Sao Rafael Salvador BA Brazil
Hospital Sirio Libanes Buenos Aires CABA Argentina
Instituto Alexander Fleming Buenos Aires CABA Argentina
Instituto D'Or de Ensino E Pesquisa Rio de Janeiro RJ Brazil
Interdisciplinary Department of Medicine University of Bari Aldo Moro Bari Italy
IRCCS Ospedale Policlinico San Martino Genoa Italy
Klinik Für Urologie Ratzeburger Allee 160 23538 Lübeck Germany
Latin American Cooperative Oncology Group LACOG Porto Alegre Brazil
Markey Cancer Center University of Kentucky Lexington KY 40536 0293 USA
Medical Oncology 1 IRCCS Regina Elena National Cancer Institute Rome Italy
Medical Oncology Department La Paz University Hospital Madrid Spain
Medical Oncology IRCCS Azienda Ospedaliero Universitaria Di Bologna Via Albertoni 15 Bologna Italy
Medical Oncology Tawam Hospital Al Ain United Arab Emirates
Medical Oncology Unit Gemelli Molise Hospital Università Cattolica del Sacro Cuore Campobasso Italy
Medical Oncology Unit Santa Chiara Hospital Trento Italy
Medical Oncology Unit University Hospital of Parma Parma Italy
National Cancer Centre Singapore Singapore Republic of Singapore
Niguarda Cancer Center Grande Ospedale Metropolitano Niguarda Milan Italy
Oncologia D'Or Fortaleza CE Brazil
Oncologia Medica Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy
Oncologia Medica Ospedale Maggiore Di Cremona Cremona Italy
Oncology 1 Unit Department of Oncology Istituto Oncologico Veneto IOV IRCCS 35128 Padua Italy
Oncology and Hematology Department Hospital Santa Lucia SHLS 716 Cj C Brasília DF 70390 700 Brazil
Oncology Institute of Vojvodina Faculty of Medicine University of Novi Sad Novi Sad Serbia
Oncology Unit 2 University Hospital of Pisa 56126 Pisa Italy
Oncology Unit A R N A S Civico Palermo Italy
Oncology Unit Macerata Hospital Via Santa Lucia 2 62100 Macerata Italy
ONCOR Life Medical Center Saltillo Mexico
Pontificia Universidade Católica Do Rio Grande Do Sul PUCRS Porto Alegre RS Brazil
SOC Oncologia Medica Azienda Ospedaliera Pugliese Ciaccio Catanzaro Italy
Southampton Experimental Cancer Medicine Centre University of Southampton Southampton UK
Unità Di Oncologia Medica Azienda Ospedaliero Universitaria Di Cagliari Cagliari Italy
Universidade Federal de Minas Gerais UFMG Belo Horizonte MG Brazil
University of Colorado Cancer Center Anschutz Medical Campus Aurora CO USA
UOC Di Oncologia Azienda Ospedaliera Di Rilievo Nazionale Cardarelli Di Napoli Naples Italy
UOC Oncologia Azienda Ospedaliera Ospedali Riuniti Marche Nord Fano Italy
UOC Oncologia Medica Ospedale A Murri Fermo Italy
UOC Oncologia Medica Ospedale Dell'alta Val D'Elsa Usl sud est Toscana Area Senese Poggibonsi Italy
Urologic Oncology Champalimaud Clinical Center 1400 038 Lisbon Portugal
Citace poskytuje Crossref.org
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- $a BACKGROUND: Concomitant medications may potentially affect the outcome of cancer patients. In this sub-analysis of the ARON-2 real-world study (NCT05290038), we aimed to assess the impact of concomitant use of proton pump inhibitors (PPI), statins, or metformin on outcome of patients with metastatic urothelial cancer (mUC) receiving second-line pembrolizumab. METHODS: We collected data from the hospital medical records of patients with mUC treated with pembrolizumab as second-line therapy at 87 institutions from 22 countries. Patients were assessed for overall survival (OS), progression-free survival (PFS), and overall response rate. We carried out a survival analysis by a Cox regression model. RESULTS: A total of 802 patients were eligible for this retrospective study; the median follow-up time was 15.3 months. PPI users compared to non-users showed inferior PFS (4.5 vs. 7.2 months, p = 0.002) and OS (8.7 vs. 14.1 months, p < 0.001). Concomitant PPI use remained a significant predictor of PFS and OS after multivariate Cox analysis. The use of statins or metformin was not associated with response or survival. CONCLUSIONS: Our study results suggest a significant prognostic impact of concomitant PPI use in mUC patients receiving pembrolizumab in the real-world context. The mechanism of this interaction warrants further elucidation.
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- $a PreBMC-MEDLINE
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- $a 2023 $b 72 $c 11 $d 3665-3682 $e 20230907 $i 1432-0851 $m Cancer immunology and immunotherapy $n Cancer Immunol Immunother $x MED00001041
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- $a Pubmed-20240109
