-
Je něco špatně v tomto záznamu ?
Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology
D. Domagała, K. Data, H. Szyller, M. Farzaneh, P. Mozdziak, S. Woźniak, M. Zabel, P. Dzięgiel, B. Kempisty
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy
Grantová podpora
NC 07082.
United States Department of Agriculture
Free Medical Journals od 2012
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2012-03-01
Open Access Digital Library od 2012-01-01
Open Access Digital Library od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources od 2012
Odkazy
PubMed
38334666
DOI
10.3390/cells13030274
Knihovny.cz E-zdroje
- MeSH
- aneurysma břišní aorty * metabolismus MeSH
- aorta metabolismus MeSH
- apoptóza genetika MeSH
- cytokiny metabolismus MeSH
- fenotyp MeSH
- lidé MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm, which is characterized by a significant bulge on the vessel surface that may have consequences, such as distention and finally rupture. Abdominal aortic aneurysm (AAA) is a major pathological condition because it affects approximately 8% of elderly men and 1.5% of elderly women. The pathogenesis of AAA involves multiple interlocking mechanisms, including inflammation, immune cell activation, protein degradation and cellular malalignments. The expression of inflammatory factors, such as cytokines and chemokines, induce the infiltration of inflammatory cells into the wall of the aorta, including macrophages, natural killer cells (NK cells) and T and B lymphocytes. Protein degradation occurs with a high expression not only of matrix metalloproteinases (MMPs) but also of neutrophil gelatinase-associated lipocalin (NGAL), interferon gamma (IFN-γ) and chymases. The loss of extracellular matrix (ECM) due to cell apoptosis and phenotype switching reduces tissue density and may contribute to AAA. It is important to consider the key mechanisms of initiating and promoting AAA to achieve better preventative and therapeutic outcomes.
Department of Physiotherapy University School of Physical Education 51 612 Wroclaw Poland
Division of Anatomy and Histology University of Zielona Góra 65 046 Zielona Góra Poland
Institute of Veterinary Medicine Nicolaus Copernicus University 87 100 Torun Poland
Physiology Graduate Faculty North Carolina State University Raleigh NC 27613 USA
Prestage Department of Poultry Science North Carolina State University Raleigh NC 27607 USA
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24007249
- 003
- CZ-PrNML
- 005
- 20240423155831.0
- 007
- ta
- 008
- 240412s2024 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/cells13030274 $2 doi
- 035 __
- $a (PubMed)38334666
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Domagała, Dominika $u Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0009000852207851
- 245 10
- $a Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology / $c D. Domagała, K. Data, H. Szyller, M. Farzaneh, P. Mozdziak, S. Woźniak, M. Zabel, P. Dzięgiel, B. Kempisty
- 520 9_
- $a A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm, which is characterized by a significant bulge on the vessel surface that may have consequences, such as distention and finally rupture. Abdominal aortic aneurysm (AAA) is a major pathological condition because it affects approximately 8% of elderly men and 1.5% of elderly women. The pathogenesis of AAA involves multiple interlocking mechanisms, including inflammation, immune cell activation, protein degradation and cellular malalignments. The expression of inflammatory factors, such as cytokines and chemokines, induce the infiltration of inflammatory cells into the wall of the aorta, including macrophages, natural killer cells (NK cells) and T and B lymphocytes. Protein degradation occurs with a high expression not only of matrix metalloproteinases (MMPs) but also of neutrophil gelatinase-associated lipocalin (NGAL), interferon gamma (IFN-γ) and chymases. The loss of extracellular matrix (ECM) due to cell apoptosis and phenotype switching reduces tissue density and may contribute to AAA. It is important to consider the key mechanisms of initiating and promoting AAA to achieve better preventative and therapeutic outcomes.
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a senioři $7 D000368
- 650 12
- $a aneurysma břišní aorty $x metabolismus $7 D017544
- 650 _2
- $a aorta $x metabolismus $7 D001011
- 650 _2
- $a cytokiny $x metabolismus $7 D016207
- 650 _2
- $a fenotyp $7 D010641
- 650 _2
- $a apoptóza $x genetika $7 D017209
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Data, Krzysztof $u Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0000000290185357
- 700 1_
- $a Szyller, Hubert $u Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0000000347814151
- 700 1_
- $a Farzaneh, Maryam $u Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran $1 https://orcid.org/0000000162398745
- 700 1_
- $a Mozdziak, Paul $u Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27607, USA $u Physiology Graduate Faculty, North Carolina State University, Raleigh, NC 27613, USA $1 https://orcid.org/0000000215753123
- 700 1_
- $a Woźniak, Sławomir $u Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0000000274507993
- 700 1_
- $a Zabel, Maciej $u Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $u Division of Anatomy and Histology, University of Zielona Góra, 65-046 Zielona Góra, Poland
- 700 1_
- $a Dzięgiel, Piotr $u Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $u Department of Physiotherapy, University School of Physical Education, 51-612 Wroclaw, Poland
- 700 1_
- $a Kempisty, Bartosz $u Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland $u Physiology Graduate Faculty, North Carolina State University, Raleigh, NC 27613, USA $u Institute of Veterinary Medicine, Nicolaus Copernicus University, 87-100 Torun, Poland $u Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 602 00 Brno, Czech Republic
- 773 0_
- $w MED00194911 $t Cells $x 2073-4409 $g Roč. 13, č. 3 (2024)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38334666 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240412 $b ABA008
- 991 __
- $a 20240423155827 $b ABA008
- 999 __
- $a ok $b bmc $g 2081315 $s 1217016
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 13 $c 3 $e 20240201 $i 2073-4409 $m Cells $n Cells $x MED00194911
- GRA __
- $a NC 07082. $p United States Department of Agriculture
- LZP __
- $a Pubmed-20240412