• Je něco špatně v tomto záznamu ?

Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review

M. Jelinek, J. Lipkova, K. Duris

. 2024 ; 372 (-) : 114628. [pub] 20231130

Jazyk angličtina Země Spojené státy americké

Typ dokumentu přehledy, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc24007375

Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24007375
003      
CZ-PrNML
005      
20240423155915.0
007      
ta
008      
240412e20231130xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.expneurol.2023.114628 $2 doi
035    __
$a (PubMed)38042360
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Jelinek, Matyas $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
245    10
$a Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review / $c M. Jelinek, J. Lipkova, K. Duris
520    9_
$a Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
650    _2
$a lidé $7 D006801
650    12
$a vagová stimulace $7 D055536
650    12
$a cévní mozková příhoda $x terapie $x metabolismus $7 D020521
650    _2
$a mikroglie $x metabolismus $7 D017628
650    _2
$a antioxidancia $x metabolismus $7 D000975
650    _2
$a nervus vagus $x fyziologie $7 D014630
650    _2
$a imunomodulace $7 D056747
655    _2
$a přehledy $7 D016454
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Lipkova, Jolana $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Duris, Kamil $u Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurosurgery, The University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: kduris@med.muni.cz
773    0_
$w MED00001749 $t Experimental neurology $x 1090-2430 $g Roč. 372 (20231130), s. 114628
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38042360 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240412 $b ABA008
991    __
$a 20240423155912 $b ABA008
999    __
$a ok $b bmc $g 2081383 $s 1217142
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 372 $c - $d 114628 $e 20231130 $i 1090-2430 $m Experimental neurology $n Exp Neurol $x MED00001749
LZP    __
$a Pubmed-20240412

Najít záznam

Citační ukazatele

Možnosti archivace