Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review
Language English Country United States Media print-electronic
Document type Review, Journal Article, Research Support, Non-U.S. Gov't
PubMed
38042360
DOI
10.1016/j.expneurol.2023.114628
PII: S0014-4886(23)00313-8
Knihovny.cz E-resources
- Keywords
- Inflammation, Stroke, Vagus nerve stimulation,
- MeSH
- Antioxidants metabolism MeSH
- Stroke * therapy metabolism MeSH
- Immunomodulation MeSH
- Humans MeSH
- Microglia metabolism MeSH
- Vagus Nerve physiology MeSH
- Vagus Nerve Stimulation * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antioxidants MeSH
Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
References provided by Crossref.org
