-
Je něco špatně v tomto záznamu ?
Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region
M. Georgieva Bacelova, P. Dimitrova Gatseva, T. Ivanova Deneva, D. Miteva Davcheva, A. Veselinova Bivolarska
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Digitální knihovna NLK
Zdroj
NLK
Free Medical Journals
od 2004
ProQuest Central
od 2009-03-01 do Před 6 měsíci
Medline Complete (EBSCOhost)
od 2006-03-01 do Před 6 měsíci
Nursing & Allied Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2009-03-01 do Před 6 měsíci
Public Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
ROAD: Directory of Open Access Scholarly Resources
od 1993
PubMed
38669155
DOI
10.21101/cejph.a7796
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- hořčík krev analýza aplikace a dávkování MeSH
- hypotyreóza epidemiologie MeSH
- jod * nedostatek aplikace a dávkování MeSH
- komplikace těhotenství epidemiologie MeSH
- lidé MeSH
- měď * nedostatek krev MeSH
- nutriční stav * MeSH
- stopové prvky nedostatek MeSH
- těhotenství MeSH
- thyreotropin krev MeSH
- zinek * nedostatek krev MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Bulharsko MeSH
OBJECTIVE: Trace elements are essential for the biochemistry of the cell. Their reference values have been found to differ considerably in pregnant women stratified by age, place of residence, anthropometric status, and length of pregnancy. In optimal amounts, these elements reduce the risk of pregnancy complications. Subclinical hypothyroidism in pregnancy is associated with adverse maternal and neonatal outcomes. The aim of the study was to determine the effects of zinc (Zn), copper (Cu), magnesium (Mg), and rubidium (Rb) on pregnant women in an iodine deficiency region and find the relationship with the thyroid status and nutrition. METHODS: We evaluated the iodine status of 61 healthy pregnant women from an iodine deficient region in Bulgaria. Thyroid stimulating hormone (TSH) and thyroxin free (FT4) levels were measured using ELISA. RESULTS: We found elevated levels of copper that differed the most between the first and second trimesters; Cu and TSH were found to be positively correlated (р < 0.05). Lower Cu levels were found in pregnant women consuming pulses more than 2-3 times a week (р = 0.033). The women consuming fish more than 2-3 times a week had higher levels of Rb. We found a pronounced iodine deficiency in more than half of the examined women in the first to third trimesters, without any effect of pregnancy on the ioduria (р=0.834). All second and third trimester cases were associated with severe ioduria (< 150 μg/L). CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.
Department of Clinical Laboratory Faculty of Pharmacy Medical University of Plovdiv Plovdiv Bulgaria
Department of Hygiene Faculty of Public Health Medical University of Plovdiv Plovdiv Bulgaria
Department of Physiology Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24008647
- 003
- CZ-PrNML
- 005
- 20250416104646.0
- 007
- ta
- 008
- 240509s2024 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.21101/cejph.a7796 $2 doi
- 035 __
- $a (PubMed)38669155
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Georgieva Bacelova, Mariana $u Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
- 245 10
- $a Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region / $c M. Georgieva Bacelova, P. Dimitrova Gatseva, T. Ivanova Deneva, D. Miteva Davcheva, A. Veselinova Bivolarska
- 520 9_
- $a OBJECTIVE: Trace elements are essential for the biochemistry of the cell. Their reference values have been found to differ considerably in pregnant women stratified by age, place of residence, anthropometric status, and length of pregnancy. In optimal amounts, these elements reduce the risk of pregnancy complications. Subclinical hypothyroidism in pregnancy is associated with adverse maternal and neonatal outcomes. The aim of the study was to determine the effects of zinc (Zn), copper (Cu), magnesium (Mg), and rubidium (Rb) on pregnant women in an iodine deficiency region and find the relationship with the thyroid status and nutrition. METHODS: We evaluated the iodine status of 61 healthy pregnant women from an iodine deficient region in Bulgaria. Thyroid stimulating hormone (TSH) and thyroxin free (FT4) levels were measured using ELISA. RESULTS: We found elevated levels of copper that differed the most between the first and second trimesters; Cu and TSH were found to be positively correlated (р < 0.05). Lower Cu levels were found in pregnant women consuming pulses more than 2-3 times a week (р = 0.033). The women consuming fish more than 2-3 times a week had higher levels of Rb. We found a pronounced iodine deficiency in more than half of the examined women in the first to third trimesters, without any effect of pregnancy on the ioduria (р=0.834). All second and third trimester cases were associated with severe ioduria (< 150 μg/L). CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a těhotenství $7 D011247
- 650 12
- $a jod $x nedostatek $x aplikace a dávkování $7 D007455
- 650 _2
- $a dospělí $7 D000328
- 650 12
- $a zinek $x nedostatek $x krev $7 D015032
- 650 12
- $a nutriční stav $7 D009752
- 650 12
- $a měď $x nedostatek $x krev $7 D003300
- 650 _2
- $a hořčík $x krev $x analýza $x aplikace a dávkování $7 D008274
- 650 _2
- $a stopové prvky $x nedostatek $7 D014131
- 650 _2
- $a komplikace těhotenství $x epidemiologie $7 D011248
- 650 _2
- $a thyreotropin $x krev $7 D013972
- 650 _2
- $a hypotyreóza $x epidemiologie $7 D007037
- 651 _2
- $a Bulharsko $x epidemiologie $7 D002031
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Dimitrova Gatseva, Penka $u Department of Hygiene, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria
- 700 1_
- $a Ivanova Deneva, Tanya $u Department of Clinical Laboratory, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria $u Division of Pharmaceutical Innovations for Personalized Medicine, Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria
- 700 1_
- $a Miteva Davcheva, Delyana $u Department of Clinical Laboratory, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria $u Division of Pharmaceutical Innovations for Personalized Medicine, Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria
- 700 1_
- $a Veselinova Bivolarska, Anelia $u Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria
- 773 0_
- $w MED00001083 $t Central European journal of public health $x 1210-7778 $g Roč. 32, č. 1 (2024), s. 31-38
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38669155 $y Pubmed
- 910 __
- $a ABA008 $b B 1829 $c 562 $y p $z 0
- 990 __
- $a 20240509 $b ABA008
- 991 __
- $a 20250416104651 $b ABA008
- 999 __
- $a ok $b bmc $g 2302961 $s 1218428
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 32 $c 1 $d 31-38 $e - $i 1210-7778 $m Central European journal of public health $n Cent Eur J Public Health $x MED00001083
- LZP __
- $b NLK116 $a Pubmed-20240509
