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Geographic variation of mutagenic exposures in kidney cancer genomes
S. Senkin, S. Moody, M. Díaz-Gay, B. Abedi-Ardekani, T. Cattiaux, A. Ferreiro-Iglesias, J. Wang, S. Fitzgerald, M. Kazachkova, R. Vangara, AP. Le, EN. Bergstrom, A. Khandekar, B. Otlu, S. Cheema, C. Latimer, E. Thomas, JR. Atkins, K. Smith-Byrne,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu srovnávací studie, časopisecké články
Grantová podpora
Wellcome Trust - United Kingdom
001
World Health Organization - International
NLK
Nature Journals Online
od 1997
Nature Journal Archive
od 1997
ProQuest Central
od 1990-01-04 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1990-01-04 do Před 1 rokem
Health & Medicine (ProQuest)
od 1990-01-04 do Před 1 rokem
Psychology Database (ProQuest)
od 1990-01-04 do Před 1 rokem
Public Health Database (ProQuest)
od 1990-01-04 do Před 1 rokem
- MeSH
- genom lidský genetika MeSH
- genomika MeSH
- hypertenze epidemiologie MeSH
- incidence MeSH
- karcinom z renálních buněk * genetika epidemiologie chemicky indukované MeSH
- kouření tabáku škodlivé účinky genetika MeSH
- kyseliny aristolochové škodlivé účinky MeSH
- lidé MeSH
- mutace * MeSH
- mutageny * škodlivé účinky MeSH
- nádory ledvin * genetika epidemiologie chemicky indukované MeSH
- obezita epidemiologie MeSH
- rizikové faktory MeSH
- vystavení vlivu životního prostředí * škodlivé účinky analýza MeSH
- zeměpis * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Japonsko MeSH
- Rumunsko MeSH
- Srbsko MeSH
- Thajsko MeSH
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden1. In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence2. Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations. Here we sequenced 962 clear cell renal cell carcinomas from 11 countries with varying incidence. The somatic mutation profiles differed between countries. In Romania, Serbia and Thailand, mutational signatures characteristic of aristolochic acid compounds were present in most cases, but these were rare elsewhere. In Japan, a mutational signature of unknown cause was found in more than 70% of cases but in less than 2% elsewhere. A further mutational signature of unknown cause was ubiquitous but exhibited higher mutation loads in countries with higher incidence rates of kidney cancer. Known signatures of tobacco smoking correlated with tobacco consumption, but no signature was associated with obesity or hypertension, suggesting that non-mutagenic mechanisms of action underlie these risk factors. The results of this study indicate the existence of multiple, geographically variable, mutagenic exposures that potentially affect tens of millions of people and illustrate the opportunities for new insights into cancer causation through large-scale global cancer genomics.
Biomedical Sciences Graduate Program University of California San Diego La Jolla CA USA
Cancer Ageing and Somatic Mutation Wellcome Sanger Institute Cambridge UK
Cancer Epidemiology Unit The Nuffield Department of Population Health University of Oxford Oxford UK
Centre for Biodiversity Genomics University of Guelph Guelph Ontario Canada
Clinic of Nephrology Faculty of Medicine Military Medical Academy Belgrade Serbia
Department of Anatomic Pathology A C Camargo Cancer Center São Paulo Brazil
Department of Bioengineering University of California San Diego La Jolla CA USA
Department of Botany and Genetics Institute of Biosciences Vilnius University Vilnius Lithuania
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA
Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Łódź Poland
Department of Epidemiology A C Camargo Cancer Center São Paulo Brazil
Department of Pathology Barretos Cancer Hospital Barretos Brazil
Department of Pathology Graduate School of Medicine The University of Tokyo Bunkyo ku Japan
Department of Pathology Radboud University Medical Centre Nijmegen Netherlands
Department of Surgery Division of Urology Sao Paulo Federal University São Paulo Brazil
Department of Urology A C Camargo Cancer Center São Paulo Brazil
Department of Urology Barretos Cancer Hospital Barretos Brazil
Department of Urology N N Blokhin National Medical Research Centre of Oncology Moscow Russia
Department of Urology University Hospital Dr D Misovic Clinical Center Belgrade Serbia
Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA
Division of Cancer Genomics National Cancer Center Research Institute Chuo ku Japan
Evidence Synthesis and Classification Branch International Agency for Research on Cancer Lyon France
Faculdade Ciências Médicas de Minas Gerais Belo Horizonte Brazil
Faculty of Health Sciences Palacky University Olomouc Czech Republic
Genomic Epidemiology Branch International Agency for Research on Cancer Lyon France
Hasheminejad Kidney Center Iran University of Medical Sciences Tehran Iran
International Organization for Cancer Prevention and Research Belgrade Serbia
Laboratory of Genetic Diagnostic National Cancer Institute Vilnius Lithuania
Latin American Renal Cancer Group São Paulo Brazil
Leeds Institute of Medical Research at St James's University of Leeds Leeds UK
Life and Health Sciences Research Institute School of Medicine Minho University Braga Portugal
Molecular Oncology Research Center Barretos Cancer Hospital Barretos Brazil
Moores Cancer Center University of California San Diego La Jolla CA USA
Nutrition and Metabolism Branch International Agency for Research on Cancer Lyon France
Observational and Pragmatic Research Institute Pte Ltd Singapore Singapore
Oncopathology Research Center Iran University of Medical Sciences Tehran Iran
Ontario Tumour Bank Ontario Institute for Cancer Research Toronto Ontario Canada
Service of Urology Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
Citace poskytuje Crossref.org
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