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Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells
M. Kulus, M. Farzaneh, A. Bryja, M. Zehtabi, S. Azizidoost, M. Abouali Gale Dari, A. Golcar-Narenji, H. Ziemak, M. Chwarzyński, H. Piotrowska-Kempisty, P. Dzięgiel, M. Zabel, P. Mozdziak, D. Bukowska, B. Kempisty, P. Antosik
Language English Country United States
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 2005-03-01 to 1 year ago
Health & Medicine (ProQuest)
from 2005-03-01 to 1 year ago
- MeSH
- Epithelial-Mesenchymal Transition * MeSH
- Phenotype MeSH
- Stem Cells metabolism cytology pathology MeSH
- Humans MeSH
- Neoplastic Cells, Circulating * pathology metabolism MeSH
- Neoplastic Stem Cells * pathology metabolism MeSH
- Neoplasms pathology metabolism MeSH
- Neovascularization, Pathologic * pathology MeSH
- Cell Proliferation genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Epithelial-mesenchymal transition (EMT) is a crucial process with significance in the metastasis of malignant tumors. It is through the acquisition of plasticity that cancer cells become more mobile and gain the ability to metastasize to other tissues. The mesenchymal-epithelial transition (MET) is the return to an epithelial state, which allows for the formation of secondary tumors. Both processes, EMT and MET, are regulated by different pathways and different mediators, which affects the sophistication of the overall tumorigenesis process. Not insignificant are also cancer stem cells and their participation in the angiogenesis, which occur very intensively within tumors. Difficulties in effectively treating cancer are primarily dependent on the potential of cancer cells to rapidly expand and occupy secondarily vital organs. Due to the ability of these cells to spread, the concept of the circulating tumor cell (CTC) has emerged. Interestingly, CTCs exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient. While EMT is necessary for metastasis, MET is required for CTCs to establish a secondary site. A thorough understanding of the processes that govern the balance between EMT and MET in malignancy is crucial.
Atherosclerosis Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran
Department of Physiotherapy Wroclaw University School of Physical Education Wroclaw Poland
Department of Toxicology Poznan University of Medical Sciences Poznan Poland
Division of Anatomy and Histology University of Zielona Góra Zielona Góra Poland
Hematology and Oncology Research Center Tabriz University of Medical Sciences Tabriz Iran
Physiology Graduate Faculty North Carolina State University Raleigh NC USA
Prestage Department of Poultry Science North Carolina State University Raleigh NC USA
Veterinary Clinic of the Nicolaus Copernicus University in Torun Torun Poland
References provided by Crossref.org
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- $a Epithelial-mesenchymal transition (EMT) is a crucial process with significance in the metastasis of malignant tumors. It is through the acquisition of plasticity that cancer cells become more mobile and gain the ability to metastasize to other tissues. The mesenchymal-epithelial transition (MET) is the return to an epithelial state, which allows for the formation of secondary tumors. Both processes, EMT and MET, are regulated by different pathways and different mediators, which affects the sophistication of the overall tumorigenesis process. Not insignificant are also cancer stem cells and their participation in the angiogenesis, which occur very intensively within tumors. Difficulties in effectively treating cancer are primarily dependent on the potential of cancer cells to rapidly expand and occupy secondarily vital organs. Due to the ability of these cells to spread, the concept of the circulating tumor cell (CTC) has emerged. Interestingly, CTCs exhibit molecular diversity and stem-like and mesenchymal features, even when derived from primary tumor tissue from a single patient. While EMT is necessary for metastasis, MET is required for CTCs to establish a secondary site. A thorough understanding of the processes that govern the balance between EMT and MET in malignancy is crucial.
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