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ALSUntangled #72: Insulin

A. Brown, C. Armon, P. Barkhaus, M. Beauchamp, T. Bertorini, M. Bromberg, JM. Cadavid, GT. Carter, J. Crayle, EL. Feldman, T. Heiman-Patterson, S. Jhooty, A. Linares, X. Li, E. Mallon, C. Mcdermott, T. Mushannen, G. Nathaniel, G. Pattee, K....

. 2024 ; 25 (3-4) : 416-419. [pub] 20231128

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu přehledy, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24014205

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review insulin, which has at least one plausible mechanism for slowing ALS progression. However, pre-clinical studies are limited and there have been no trials in PALS yet. Insulin use in patients without a metabolic need may cause very serious and potentially lethal side effects. While further studies to evaluate potential benefits may be warranted, at this time we cannot endorse insulin treatment to slow ALS progression.

Citace poskytuje Crossref.org

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$a ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review insulin, which has at least one plausible mechanism for slowing ALS progression. However, pre-clinical studies are limited and there have been no trials in PALS yet. Insulin use in patients without a metabolic need may cause very serious and potentially lethal side effects. While further studies to evaluate potential benefits may be warranted, at this time we cannot endorse insulin treatment to slow ALS progression.
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$a Barkhaus, Paul $u Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA $1 https://orcid.org/0000000182688643
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$a Beauchamp, Morgan $u UNC Health, UNC, Chapel Hill, NC, USA
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$a Bertorini, Tulio $u Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA
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$a Bromberg, Mark $u Department of Neurology, University of Utah, Salt Lake City, UT, USA
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$a Cadavid, Javier Mascias $u ALS Department, Hospital Carlos III-La Paz, Madrid, Spain
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$a Carter, Gregory T $u Department of Rehabilitation, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
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$a Crayle, Jesse $u Department of Neurology, St. Louis, MO, USA
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$a Feldman, Eva L $u Department of Neurology, University of Michigan, Ann Arbor, MI, USA
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$a Heiman-Patterson, Terry $u Department of Neurology, Temple Health, Philadelphia, PA, USA
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$a Linares, Alexandra $u Medical School, Duke University, Durham, NC, USA
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$a Li, Xiaoyan $u Department of Neurology, Duke University, Durham, NC, USA
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$a Mallon, Elise $u Undergraduate, Duke University, Durham, NC, USA
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$a Mushannen, Tasnim $u Department of Neurology, Duke University, Durham, NC, USA
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$a Pattee, Gary $u Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA
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$a Pierce, Kaitlyn $u Department of Neuroscience, University of North Carolina, Chapel Hill, NC, USA
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$a Ratner, Dylan $u Undergraduate, Tulane University, New Orleans, LA, USA
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$a Slactova, Lenka $u Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic, and
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$a Wicks, Paul $u Independent Consultant, Lichfield, England, UK $1 https://orcid.org/0000000222939284
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