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The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly

J. Chen, J. Bartoš, A. Boudichevskaia, A. Voigt, MT. Rabanus-Wallace, S. Dreissig, Z. Tulpová, H. Šimková, J. Macas, G. Kim, J. Buhl, K. Bürstenbinder, FR. Blattner, J. Fuchs, T. Schmutzer, A. Himmelbach, V. Schubert, A. Houben

. 2024 ; 15 (1) : 9686. [pub] 20241108

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25003495

Grant support
HO1779/30-1 Deutsche Forschungsgemeinschaft (German Research Foundation)
HO1779/30-2 Deutsche Forschungsgemeinschaft (German Research Foundation)
HO1779/34-1 Deutsche Forschungsgemeinschaft (German Research Foundation)

The genomes of many plants, animals, and fungi frequently comprise dispensable B chromosomes that rely upon various chromosomal drive mechanisms to counteract the tendency of non-essential genetic elements to be purged over time. The B chromosome of rye - a model system for nearly a century - undergoes targeted nondisjunction during first pollen mitosis, favouring segregation into the generative nucleus, thus increasing their numbers over generations. However, the genetic mechanisms underlying this process are poorly understood. Here, using a newly-assembled, ~430 Mb-long rye B chromosome pseudomolecule, we identify five candidate genes whose role as trans-acting moderators of the chromosomal drive is supported by karyotyping, chromosome drive analysis and comparative RNA-seq. Among them, we identify DCR28, coding a microtubule-associated protein related to cell division, and detect this gene also in the B chromosome of Aegilops speltoides. The DCR28 gene family is neo-functionalised and serially-duplicated with 15 B chromosome-located copies that are uniquely highly expressed in the first pollen mitosis of rye.

References provided by Crossref.org

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$a The genomes of many plants, animals, and fungi frequently comprise dispensable B chromosomes that rely upon various chromosomal drive mechanisms to counteract the tendency of non-essential genetic elements to be purged over time. The B chromosome of rye - a model system for nearly a century - undergoes targeted nondisjunction during first pollen mitosis, favouring segregation into the generative nucleus, thus increasing their numbers over generations. However, the genetic mechanisms underlying this process are poorly understood. Here, using a newly-assembled, ~430 Mb-long rye B chromosome pseudomolecule, we identify five candidate genes whose role as trans-acting moderators of the chromosomal drive is supported by karyotyping, chromosome drive analysis and comparative RNA-seq. Among them, we identify DCR28, coding a microtubule-associated protein related to cell division, and detect this gene also in the B chromosome of Aegilops speltoides. The DCR28 gene family is neo-functionalised and serially-duplicated with 15 B chromosome-located copies that are uniquely highly expressed in the first pollen mitosis of rye.
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$a Buhl, Jonas $u Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany $u Institute of Biology, Department of Plant Cell Biology, Philipps University Marburg, Marburg, Germany
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$a Himmelbach, Axel $u Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany
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