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Association of Total Mortality and Cardiovascular Endpoints With the Timing of the First and Second Systolic Peak of the Aortic Pulse Wave

YB. Cheng, DW. An, LS. Aparicio, QF. Huang, YL. Yu, CS. Sheng, TJ. Niiranen, FF. Wei, J. Boggia, K. Stolarz-Skrzypek, N. Gilis-Malinowska, V. Tikhonoff, W. Wojciechowska, E. Casiglia, K. Narkiewicz, WY. Yang, J. Filipovský, K. Kawecka-Jaszcz, JG....

. 2025 ; 27 (1) : e14962. [pub] -

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25010395

Grantová podpora
The Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires
HEALTH-F7-305507 HOMAGE Belgium (Leuven): European Union
2011-294713-EPLORE European Research Council - International
713601-uPROPHET European Research Council - International
JTC2017-046-PROACT European Research Area Net for Cardiovascular Diseases
82070432 National Natural Science Foundation of China
82070435 National Natural Science Foundation of China
82270469 National Natural Science Foundation of China
81970353 National Natural Science Foundation of China
2022YFC3602400 National Key Research and Development Projects
2022YFC3602401 National Key Research and Development Projects
19ZR144330 Shanghai Commissions of Science and Technology
21TS1400300 Shanghai Commissions of Science and Technology
SHDC2020CR1042B Shanghai Shenkang Hospital Development Center
20234Y0036 Shanghai Municipal Health Commission
202340035 Shanghai Municipal Health Commission
201940297 Shanghai Municipal Health Commission
GWV-10.1-XK05 Shanghai Municipal Health Commission
2022LJ022 Shanghai Municipal Health Commission
LSHM-CT-2006-037093 Czech Republic: European Union
HEALTH-F4-2007-201550 Czech Republic: European Union
Charles University Research Fund
Finnish Research Council
Finnish Foundation for Cardiovascular Research
LSHM-CT-2006037093 Italy: European Union
HEALTH-F4-2007201550 Italy: European Union
LSHM-CT-2006037093 Poland (Gdańsk): European Union
HEALTH-F4-2007201550 Poland (Gdańsk): European Union
LSHM-CT-2006037093 Poland (Kraków): European Union
HEALTH-F4-2007201550 Poland (Kraków): European Union
Foundation for Polish Science

Prognostic significance of the timing in the cardiac cycle of the first (TP1) and second (TP2) systolic peak of the central aortic pulse wave is ill-defined. Incidence rates and standardized multivariable-adjusted hazard ratios (HRs) of adverse health outcomes associated with TP1 and TP2, estimated by the SphygmoCor software, were assessed in the International Database of Central Arterial Properties for Risk Stratification (IDCARS) (n = 5529). Model refinement was assessed by the integrated discrimination (ID) and net reclassification (NR) improvement. Over 4.1 years (median), 201 participants died and 248 and 159 patients experienced cardiovascular or cardiac endpoints. Mean TP1 and TP2, standardized for cohort, sex, age, and heart rate, were 103 and 228 ms. Shorter TP1 and TP2 were associated with higher mortality and shorter TP1 with a higher risk of cardiovascular and cardiac endpoints (trend p ≤ 0.004). The HRs relating total mortality and cardiovascular endpoints to TP2 were 0.82 (95% confidence interval [CI]: 0.72-0.94) and 0.87 (0.77-0.98), respectively. The HR relating cardiac endpoints to TP1 was 0.81 (0.68-0.97). For total mortality and cardiovascular endpoints in relation to TP2, NRI was significant (p ≤ 0.010), but not for cardiac endpoints in relation to TP1. Integrated discrimination improvement (IDI) was not significant for any endpoint. The HRs relating total mortality to TP2 were smaller (p ≤ 0.026) in women than men (0.67 vs. 0.95) and in older (≥ 60 years) versus younger (< 60 years) participants (0.80 vs. 0.88). Our study adds to the evidence supporting risk stratification based on aortic pulse analysis by showing that TP2 and TP1 carry prognostic information.

1st Department of Cardiology Interventional Electrocardiology and Hypertension Jagiellonian University Medical College Kraków Poland

Biomedical Sciences Group Faculty of Medicine University of Leuven Leuven Belgium

Centro de Nefrología and Departamento de Fisiopatología Hospital de Clínicas Universidad de la República Montevideo Uruguay

Department of Cardiology Shanghai General Hospital Shanghai China

Department of Cardiology the 1st Affiliated Hospital of Sun Yat Sen University Guangzhou Guangdong China

Department of Cardiovascular Medicine Shanghai Key Laboratory of Hypertension Shanghai Institute of Hypertension State Key Laboratory of Medical Genomics National Research Centre for Translational Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China

Department of Chronic Disease Prevention Finnish Institute for Health and Welfare Turku Finland

Department of Medicine Turku University Hospital and University of Turku Turku Finland

Department of Medicine University of Padua Padua Italy

Faculty of Medicine Charles University Pilsen Czech Republic

Hypertension Unit Department of Hypertension and Diabetology Medical University of Gdańsk Gdańsk Poland

Non Profit Research Association Alliance for the Promotion of Preventive Medicine Leuven Belgium

Research Institute Alliance for the Promotion of Preventive Medicine Mechelen Belgium

Research Unit Environment and Health Department of Public Health and Primary Care University of Leuven Leuven Belgium

Servicio de Clínica Médica Sección Hipertensión Arterial Hospital Italiano de Buenos Aires Buenos Aires Argentina

Citace poskytuje Crossref.org

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