The involvement of different regions of the brain in the immune response was investigated with the aid of small electrolytic lesions. The lesions were placed in such a way that they covered different areas of the brain stem, basal ganglia, but also some parts of the frontal cortex. The cellular immune response as well as DNA synthesis with the aid of labelled precursors was measured. The results suggest the possibility of the existence of three circuits. One circuit represents catecholaminergic cell group A1-7 in reticular formation, nucleus parabrachialis and central ncl. amygdalae. The second circuit represents serotonergic rapheal groups B6.8, hypothalamus and ncl. basomedialis of amygdala. The third circuit represents ncl. amygdalae and the medial part of frontal cortex, namely the cingulate cortex area 1-2. The close correlation between the changes of the immune response and the CNS activity was also investigated in the experiments with immunosuppressed and immunostimulated animals by measuring of the turnover of some neurotransmitters but also by recording electrocephalographic activity.

Institute of Pharmacology Czechoslovak Academy of Sciences Prague

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