Cistá aplázie erythropoézy u chronické lymfatické leukémie. Uspĕsná lécba imunosupresí
[Pure red cell aplasia in chronic lymphatic leukemia. Successful treatment using immunosuppression]
Language Czech Country Czech Republic Media print
Document type Case Reports, Journal Article
PubMed
2115704
- MeSH
- Antilymphocyte Serum therapeutic use MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell complications MeSH
- Red-Cell Aplasia, Pure etiology therapy MeSH
- Cyclophosphamide administration & dosage MeSH
- Immunosuppression Therapy * MeSH
- Middle Aged MeSH
- Humans MeSH
- Prednisone administration & dosage MeSH
- Aged MeSH
- T-Lymphocytes MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Antilymphocyte Serum MeSH
- Cyclophosphamide MeSH
- Prednisone MeSH
The authors describe two cases of chronic lympocytic leukaemia complicated by pure red cell aplasia of autoimmune origin. The first patient achieved complete recovery of erythropoiesis after short-term immunosuppression by means of cyclophosphamide and prednisone. The second patient did not respond to the same combination of immunosuppressive drugs and remission was achieved by administration of antithymocyte globulin. In the discussion the authors deal with contemporary knowledge of the pathogenesis of autoimmune erythroblastopenia and mechanismus of action of antithymocyte globulin.
