Comparison of cardiopulmonary response to intermittent high-altitude hypoxia in young and adult rats
Language English Country Switzerland Media print
Document type Comparative Study, Journal Article
PubMed
2532385
DOI
10.1159/000195778
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Adaptation, Physiological MeSH
- Hemodynamics physiology MeSH
- Hypoxia complications physiopathology MeSH
- Rats, Inbred Strains MeSH
- Cardiomegaly etiology physiopathology MeSH
- Rats MeSH
- Altitude * MeSH
- Hypertension, Pulmonary etiology physiopathology MeSH
- Pulmonary Wedge Pressure physiology MeSH
- Aging physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
Haemodynamic and heart weight parameters were compared in male rats exposed to intermittent high-altitude (IHA) hypoxia (barochamber, 8 h/day, 5 days/week, total of 24 exposures stepwise up to 7,000 m) starting either from the 4th day or the 12th week of postnatal life. Systemic arterial pressure and heart rate increased in adult IHA acclimatized animals only. Marked chronic pulmonary hypertension and right ventricular enlargement were found in both age groups. Right ventricular weight increased linearly with a rise of pulmonary blood pressure in animals exposed to IHA from the 4th day of life (r = 0.72); no significant relation was found in adult rats (r = 0.16). The close correlation between both variables in young hypoxic rats may be due to the ability of the developing heart to respond to chronic hypoxia by both hypertrophy and hyperplasia of myocytes.
References provided by Crossref.org
Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences
Right ventricular function in rats with hypoxic pulmonary hypertension
