The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis
Language English Country Czech Republic Media print
Document type Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial
PubMed
2663343
Knihovny.cz E-resources
- MeSH
- Analgesics administration & dosage MeSH
- Anticoagulants administration & dosage MeSH
- Arteriosclerosis Obliterans drug therapy MeSH
- Aspirin administration & dosage analogs & derivatives MeSH
- Leg blood supply MeSH
- Adult MeSH
- Hemodynamics drug effects MeSH
- Hydroxyethylrutoside administration & dosage analogs & derivatives MeSH
- Ischemia drug therapy MeSH
- Clinical Trials as Topic MeSH
- Drug Therapy, Combination MeSH
- Middle Aged MeSH
- Humans MeSH
- Plethysmography MeSH
- Rutin analogs & derivatives MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Randomized Controlled Trial MeSH
- Comparative Study MeSH
- Names of Substances
- aloxiprin MeSH Browser
- Analgesics MeSH
- Anticoagulants MeSH
- Aspirin MeSH
- Hydroxyethylrutoside MeSH
- Rutin MeSH
- troxevasin MeSH Browser
The effect of 7-mono-hydroxyethylrutoside and its combination with acetylsalicylic acid was evaluated in a controlled clinical trial, performed in 105 patients with obliterative atherosclerosis of the lower limbs, and using non-invasive measurement of peripheral haemodynamic parameters--blood flow during reactive hyperaemia and ankle systolic blood pressure. Patients, randomized into three groups, received either placebo or 7-mono-hydroxyethylrutoside alone or in combination with acetylsalicylic acid for 12 months. The placebo group showed a decrease in maximum calf blood flow and a decrease in ankle systolic pressure. Administration of 7-mono-hydroxyethylrutoside did not lead to any significant changes in systolic pressure but there was a decrease in the maximum calf blood flow. There were no statistically significant changes in patients receiving the 7-mono-hydroxyethylrutoside and acetylsalicylic acid combination who, by contrast, showed a tendency to increased values of the parameters measured.
