Effects of flunarizine on Metrazol-induced seizures in developing rats
Language English Country Netherlands Media print
Document type Journal Article
PubMed
3504406
DOI
10.1016/0920-1211(87)90006-4
PII: 0920-1211(87)90006-4
Knihovny.cz E-resources
- MeSH
- Anticonvulsants therapeutic use MeSH
- Flunarizine therapeutic use MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Pentylenetetrazole * therapeutic use MeSH
- Aging physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced drug therapy physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anticonvulsants MeSH
- Flunarizine MeSH
- Pentylenetetrazole * MeSH
Antimetrazol action of flunarizine (5, 10, 20 and 40 mg/kg i.p.) was tested during ontogenesis on male Wistar rats aged 7, 12, 18, 25 and 90 days. The latencies and incidences of jerks, minimal Metrazol seizures and major Metrazol seizures remained unchanged by flunarizine in all age groups. A specific action (an abolition of the tonic phase of major seizures) was seen throughout the development and was reflected in lower scores of seizures.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats
Convulsant action of a benzodiazepine receptor agonist/inverse agonist Ro 19-4603 in developing rats
Pentylenetetrazol-induced seizures in rats: an ontogenetic study
