The rat suprachiasmatic nucleus is a clock for all seasons
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.
Grantová podpora
F05 TWO 4638
FIC NIH HHS - United States
R01 NS24542
NINDS NIH HHS - United States
PubMed
7644490
PubMed Central
PMC41224
DOI
10.1073/pnas.92.17.7754
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- cirkadiánní rytmus * MeSH
- cykly aktivity MeSH
- exprese genu MeSH
- geny fos MeSH
- hybridizace in situ MeSH
- krysa rodu Rattus MeSH
- messenger RNA analýza biosyntéza MeSH
- nucleus suprachiasmaticus fyziologie MeSH
- potkani Wistar MeSH
- protoonkogenní proteiny c-fos biosyntéza MeSH
- světlo MeSH
- tma MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Názvy látek
- messenger RNA MeSH
- protoonkogenní proteiny c-fos MeSH
Seasonal changes of daylength (photoperiod) affect the expression of hormonal and behavioral circadian rhythms in a variety of organisms. In mammals, such effects might reflect photoperiodic changes in the circadian pace-making system [located in the suprachiasmatic nucleus (SCN) of the hypothalamus] that governs these rhythms, but to date no functionally relevant, intrinsic property of the SCN has been shown to be photoperiod dependent. We have analyzed the temporal regulation of light-induced c-fos gene expression in the SCN of rats maintained in long or short photoperiods. Both in situ hybridization and immunohistochemical assays show that the endogenous circadian rhythm of light responsiveness in the SCN is altered by photoperiod, with the duration of the photosensitive subjective night under the short photoperiod 5-6 h longer than under the long photoperiod. Our results provide evidence that a functional property of the SCN is altered by photoperiod and suggest that the nucleus is involved in photoperiodic time measurement.
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