DNA diagnosis uses for identification of disorders of the mitochondrial genome currently used methods of restrictive analysis by selective proliferation of selected sections of the mtDNA by polymerase chain reaction (PCR) and sequence. With regard to the considerable natural variability it is essential to evaluate very carefully the assembled results and provide evidence of a causal relationship of changes found in mtDNA and morphological, biochemical and clinical symptoms.

Ustav hematologie a krevní transfuze odd molekulární genetiky Praha