Enzymic and permeability activity of Pseudomonas aeruginosa after treatment with sub-MICs of organic ammonium salts
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
7995601
DOI
10.1007/bf02814648
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- fosfolipasy typu C antagonisté a inhibitory MeSH
- inhibitory proteas farmakologie MeSH
- kapilární permeabilita MeSH
- kvartérní amoniové sloučeniny farmakologie MeSH
- mikrobiální testy citlivosti MeSH
- pankreatická elastasa antagonisté a inhibitory MeSH
- Pseudomonas aeruginosa účinky léků enzymologie patogenita MeSH
- virulence MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- fosfolipasy typu C MeSH
- inhibitory proteas MeSH
- kvartérní amoniové sloučeniny MeSH
- pankreatická elastasa MeSH
The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of 12 organic ammonium salts of A (hard-alkyltrimethylammonium bromides) and B (soft--2-(dodecanoylamino)ethylalkyldimethylammonium bromides) homologous series on phospholipase C, proteinase, elastase and permeability activity were studied. The substances with longer substituents were more effective in reducing phospholipase C activity (hard and soft series) as well as proteinase (hard series). Phospholipase C was the most frequently and the most markedly inhibited enzyme. The organic ammonium salts were less effective in inhibiting elastase and permeability activity. Only one of the substances under study reduced all the tested activities.
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