Growth and conidiation of Trichoderma viride are affected by non-steroidal antiinflammatory agents
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
8181781
DOI
10.1007/bf02814528
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents, Non-Steroidal pharmacology MeSH
- Cell Differentiation drug effects MeSH
- Species Specificity MeSH
- Mitosporic Fungi drug effects physiology MeSH
- Saccharomyces cerevisiae drug effects physiology MeSH
- Spores, Fungal MeSH
- Trichoderma drug effects physiology MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Inflammatory Agents, Non-Steroidal MeSH
Nonsteroid antiinflammatory agents (NSAIA's) (inhibitors of cyclooxygenase and lipoxygenase) of several structural series inhibited growth of Trichoderma viride. The most potent growth inhibitors were indomethacin and its derivative repanidal which inhibited in the range of 0.1 mmol/L. The weakest inhibitors were acetylsalicylic acid and lysine salicylate which exerted only a weak effect at concentrations above 1 mmol/L. The inhibition of growth was accompanied by a stimulation of conidiation in the dark. A light pulse increased the efficiency of these drugs to stimulate the conidiation. Saccharomyces cerevisiae was as sensitive to NSAIA's as T. viride while Botrytis cinerea was less sensitive. The results indicate that arachidonate metabolism may play a role in the growth of fungi and may participate also in the process of conidiation.
