Inhibition of intercellular gap junctional communication by alkyl ethers and its modulation by cAMP
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
8394517
Knihovny.cz E-zdroje
- MeSH
- buněčné linie MeSH
- časové faktory MeSH
- dibutyryl cyklický AMP antagonisté a inhibitory farmakologie toxicita MeSH
- ethylenglykol MeSH
- ethylenglykoly antagonisté a inhibitory toxicita MeSH
- kofein farmakologie MeSH
- křečci praví MeSH
- lékové interakce MeSH
- methylethery antagonisté a inhibitory toxicita MeSH
- mezibuněčná komunikace účinky léků MeSH
- mezibuněčné spoje účinky léků fyziologie MeSH
- polyethylenglykoly toxicita MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- křečci praví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- dibutyryl cyklický AMP MeSH
- ethylenglykol MeSH
- ethylenglykoly MeSH
- kofein MeSH
- methylethery MeSH
- polyethylenglykoly MeSH
The inhibition of intercellular gap junctional communication (IGJC) by alkyl ethers (ethylene glycol, monomethyl ether, polyethylene glycol 1,000 and polyethylene glycol 6000) was examined using V79 Chinese hamster cells in vitro. Ethylene glycol and monomethyl ether inhibited IGJC very strongly, whilst the other agents inhibited IGJC only insignificantly. When the cells were treated with the combination of two agents, ethylene glycol and monomethyl ether, a significant increase in the inhibition of IGJC occurred. This was probably the result of potentiation rather than an addition effect. The effect of ethylene glycol was antagonized by dibutyryl cyclic adenosine monophosphate (DbcAMP). This effect was most intensive when the cells were treated with both agents at the same time and, in other experimental combinations, the effect was lower but also significant. Caffeine did not influence IGJC either in combination with DbcAMP or by itself.
