A novel method for glycoconjugate synthesis
Language English Country United States Media print
Document type Journal Article
PubMed
8872126
DOI
10.1007/bf00731457
Knihovny.cz E-resources
- MeSH
- Chymotrypsin chemistry MeSH
- Glycoconjugates chemical synthesis MeSH
- Glycosides chemistry MeSH
- Glycosylation MeSH
- Indicators and Reagents MeSH
- Serum Albumin, Bovine chemistry MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Chymotrypsin MeSH
- Glycoconjugates MeSH
- Glycosides MeSH
- Indicators and Reagents MeSH
- Serum Albumin, Bovine MeSH
2-Chloroethyl 1-thio-beta-D-galactopyranoside and the corresponding 1-thio-beta-D-glucopyranoside have been found to be suitable glycosylating agents for the preparation of different types of glycoconjugates. Glycosylation of bovine serum albumin and chymotrypsin were chosen as examples of an application of the described compounds. The glycosylating agents can modify not only amino groups, but also alkyl hydroxyl and aryl hydroxyl groups, as was shown in experiments with model water soluble and water insoluble polyacrylamide copolymers.
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