Dent's disease--the hypercalciuric variant of Fanconi's syndrome
Language English Country Czech Republic Media print
Document type Case Reports, Journal Article
PubMed
9748795
Knihovny.cz E-resources
- MeSH
- Fanconi Syndrome complications urine MeSH
- Humans MeSH
- Chronic Kidney Disease-Mineral and Bone Disorder complications MeSH
- Adolescent MeSH
- Proteinuria MeSH
- Calcium urine MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Calcium MeSH
Dent's disease is a rare type of proximal renal tubular defect characterized by hypercalciuria, low-molecular-weight (LMW) proteinuria, nephrocalcinosis and slowly progressive renal failure, short stature and osteopenia in children with clinical symptoms of rickets. This "hypercalciuric rickets" was originally described by Charles Dent and Max Friedman in 1964 [1]. The disease is probably linked to the X chromosome so that males are much more severely affected than females.
