Melatonin inhibits the increase of cyclic AMP in rat suprachiasmatic neurons induced by vasoactive intestinal peptide
Language English Country Ireland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9756349
DOI
10.1016/s0304-3940(98)00530-8
PII: S0304-3940(98)00530-8
Knihovny.cz E-resources
- MeSH
- Cyclic AMP metabolism MeSH
- Antioxidants pharmacology MeSH
- Circadian Rhythm physiology MeSH
- Rats MeSH
- Melatonin pharmacology MeSH
- Neurons drug effects metabolism MeSH
- Suprachiasmatic Nucleus cytology MeSH
- Rats, Wistar MeSH
- Vasoactive Intestinal Peptide pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cyclic AMP MeSH
- Antioxidants MeSH
- Melatonin MeSH
- Vasoactive Intestinal Peptide MeSH
The effects of melatonin on basal and vasoactive intestinal peptide (VIP)-induced cAMP concentration was studied in dispersed cells of the rat suprachiasmatic nuclei (SCN). Our data indicate, that VIP induces a rapid increase of cAMP concentration in the cells followed by a slow and prolonged increase in the medium. The VIP-induced increase was dose-dependent in the range of 1-100 nM. Melatonin had no effect on basal cAMP but inhibited the cAMP increase induced by VIP in a dose-dependent manner (EC50 = 0.21 nM). Our observations indicate that melatonin acts through the inhibition of cAMP in the SCN cells similar as shown in other tissues.
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