Hydration of the phosphate group in double-helical DNA
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Grant support
GM21589
NIGMS NIH HHS - United States
PubMed
9788937
PubMed Central
PMC1299916
DOI
10.1016/s0006-3495(98)77686-6
PII: S0006-3495(98)77686-6
Knihovny.cz E-resources
- MeSH
- DNA chemistry MeSH
- Phosphates chemistry MeSH
- Nucleic Acid Conformation MeSH
- Models, Molecular MeSH
- Oligodeoxyribonucleotides chemistry MeSH
- Binding Sites genetics MeSH
- Water chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Names of Substances
- DNA MeSH
- Phosphates MeSH
- Oligodeoxyribonucleotides MeSH
- Water MeSH
Water distributions around phosphate groups in 59 B-, A-, and Z-DNA crystal structures were analyzed. It is shown that the waters are concentrated in six hydration sites per phosphate and that the positions and occupancies of these sites are dependent on the conformation and type of nucleotide. The patterns of hydration that are characteristic of the backbone of the three DNA helical types can be attributed in part to the interactions of these hydration sites.
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