Hydration of the DNA bases is local
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
Grant support
GM21589
NIGMS NIH HHS - United States
PubMed
8599672
PubMed Central
PMC1236503
DOI
10.1016/s0006-3495(95)80136-0
PII: S0006-3495(95)80136-0
Knihovny.cz E-resources
- MeSH
- Adenine MeSH
- Cytosine MeSH
- Databases, Factual MeSH
- DNA chemistry MeSH
- Guanine MeSH
- Nucleic Acid Conformation * MeSH
- Crystallography, X-Ray MeSH
- Models, Molecular MeSH
- Molecular Sequence Data MeSH
- Oligodeoxyribonucleotides chemistry MeSH
- Base Sequence MeSH
- Thymine MeSH
- Hydrogen Bonding MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Comparative Study MeSH
- Names of Substances
- Adenine MeSH
- Cytosine MeSH
- DNA MeSH
- Guanine MeSH
- Oligodeoxyribonucleotides MeSH
- Thymine MeSH
Ordered hydration sites were determined for the nucleotide bases in B-type conformations using the crystal structure data on 14 B-DNA decamer structures. A method of density representation was extended so that positions, occupancies, and distributions of the hydration sites were predicted around a B-DNA double helix by a method analogous to crystallographic refinement. The predicted hydration sites correctly reproduce the main features of hydration around the B-DNA dodecamer. In contrast to the previous observations, the newly available crystal data show the same extent of hydration of guanine and adenine, and of cytosine and thymine.
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