In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers University and how it became a testbed for the current infrastructure of the RCSB Protein Data Bank. We describe some of the special features of the NDB and how it has been used to enable research. Plans for the next phase as the Nucleic Acid Knowledgebase (NAKB) are summarized.

Department of Chemistry and Chemical Biology Rutgers The State University of New Jersey Piscataway NJ 08854 USA

Institute for Quantitative Biomedicine Rutgers The State University of New Jersey Piscataway NJ 08854 USA

Institute of Biotechnology of the Czech Academy of Sciences 252 50 Vestec Czech Republic

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