Gentamicin resistance in clinical strains of Enterobacteriaceae associated with reduced gentamicin uptake
Language English Country United States Media print
Document type Journal Article
PubMed
9821296
DOI
10.1007/bf02818588
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Microbial genetics MeSH
- Enterobacteriaceae drug effects growth & development isolation & purification MeSH
- Enterobacteriaceae Infections microbiology MeSH
- Escherichia coli drug effects genetics MeSH
- Gentamicins metabolism pharmacology MeSH
- Klebsiella drug effects genetics MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Plasmids genetics MeSH
- Proteus drug effects genetics MeSH
- Providencia drug effects genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Gentamicins MeSH
Seven strains of Enterobacteriaceae resistant to gentamicin obtained as representatives of the predominant resistance profiles in the clinical laboratories of Rafeidia and Al-Watani Hospitals in Nablus (Palestine) were included. Five strains showed a broad aminoglycoside resistance profile but contained no evidence of gentamicin acetylation, adenylation, or phosphorylation. Gentamicin uptake in two tested strains was significantly reduced, compared to that of gentamicin-sensitive E. coli (MIC, 0.5 microgram/mL). These strains are likely resistant due to a relative reduction of the amount of gentamicin and other aminoglycosides entering the bacterial cell. Two strains showed evidence of adenyltransferase ANT(2")-I activity.
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