Expression of CD2 on porcine B lymphocytes
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9824509
PubMed Central
PMC1364412
DOI
10.1046/j.1365-2567.1998.00621.x
Knihovny.cz E-zdroje
- MeSH
- antigeny CD2 metabolismus MeSH
- buněčná diferenciace imunologie MeSH
- diferenciační antigeny metabolismus MeSH
- gnotobiologické modely MeSH
- imunofenotypizace MeSH
- infekce vyvolané Escherichia coli imunologie MeSH
- kostní dřeň imunologie MeSH
- leukocyty mononukleární imunologie MeSH
- podskupiny B-lymfocytů imunologie MeSH
- prasata imunologie MeSH
- průtoková cytometrie MeSH
- stárnutí imunologie MeSH
- střeva mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antigeny CD2 MeSH
- diferenciační antigeny MeSH
Remarkable interspecies differences in CD2 expression on B lymphocytes have been reported in mammals. Human and rat B cells lack CD2, whilst B lymphocytes in mice are CD2+. In pigs, B cells have been supposed not to express CD2. We show here, however, that CD2 is present at a low level on a prominent subset of porcine B cells. Moreover, we describe changes in the proportions of CD2+ and CD2- B-cell subsets during ontogeny. Before contact with microflora, the majority of peripheral surface immunoglobulin M+ (sIgM+) B cells express CD2 and sIgM+CD2- B cells are rare. Shortly after colonization of conventional (CV) piglets with complex intestinal microflora, numerous CD2- B cells appear in the periphery and their relative number increases with age in both CV and specific pathogen-free (SPF) pigs. However, monoassociation of germ-free (GF) piglets with a single Escherichia coli strain does not result in a significant increase of sIgM+CD2- B cells in the periphery. We suggest that CD2 is down-regulated in porcine B lymphocytes upon activation with microflora in mucosa-associated lymphatic tissues. In bone marrow (BM), we identified putative porcine B-cell precursors. These cells express CD2 at low density and do not bear either the common myelomonocytic antigen or T and B-lymphocyte receptors. Similar to mouse and human pre-B cells, this lymphocyte-sized subset expresses CD25 and class II antigens. CD2 positivity of these cells indicates that CD2 is expressed earlier than sIgM during B lymphopoiesis in pigs.
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