Stúdium kinetiky hydrolýzy acylderivátov stobadínu, prodrug foriem zhásacov voĺnyých kyslíkových radikálov. 2. Cast: Alkalická hydrolýza
[Kinetics of hydrolysis of acylderivatives of stobadine, prodrug forms of free oxygen radical scavengers. Part 2: alkaline hydrolysis]
Language Slovak Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
11077733
- MeSH
- Hydrolysis MeSH
- Carbolines chemistry MeSH
- Hydrogen-Ion Concentration MeSH
- Prodrugs chemistry MeSH
- Free Radical Scavengers chemistry MeSH
- Spectrophotometry, Ultraviolet MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- dicarbine MeSH Browser
- Carbolines MeSH
- Prodrugs MeSH
- Free Radical Scavengers MeSH
Stobadin, (-)-cis-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyridol[4,3b]- indol is a compound with a potential antiarrhythmic, antihistamine, anaesthetic, antiulcerous, and marked antioxidative effect. N5-acylsubstitution of stobadin yielded derivatives, which represent prodrug forms of the active principle--stobadin, and it is assumed that they will be hydrolysed in the organism and the active principle will be released in higher concentrations in various biological tissues. The present paper deals with the investigation of the kinetics of hydrolysis of 13 stobadin acylderivatives in a medium of 0.1 mol/l of sodium hydroxide at 70 degrees C, employing spectrophotometry in the UV region of the spectrum. The determined rate constants were correlated with the length of the side acyl chain and the pKa values of the compounds under study.
