Cholinesterázy a jejich význam v etiologii, diagnostice a terapii Alzheimerovy nemoci
[Cholinesterases and their importance in the etiology, diagnosis and therapy of Alzheimer's disease]
Language Czech Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
11268561
- MeSH
- Acetylcholinesterase analysis physiology MeSH
- Alzheimer Disease diagnosis enzymology physiopathology therapy MeSH
- Butyrylcholinesterase analysis physiology MeSH
- Cholinesterase Inhibitors therapeutic use MeSH
- Clinical Enzyme Tests MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Butyrylcholinesterase MeSH
- Cholinesterase Inhibitors MeSH
Cholinesterases belong to esterases and represent important animal enzymes with multiple biological function. Acetylcholinesterase (AChE) plays the key role in cholinergic neurotransmission, whereas the function of butyrylcholinesterase (BuChE) is still unrevealed. Both enzymes seem to act as neurogenic factors during the early embryogenesis and later on they may participate in some pathological alteration. In humans, these degenerative changes are related to the deposition of pathologic proteins in the brain and with the progress of the Alzheimer's dementia (AD). Both AChE) and BuChE become recently the target for the most frequently used therapy of AD--cholinesterase inhibitors.
