Significance of P-glycoprotein expression in childhood malignant tumors
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11949840
Knihovny.cz E-resources
- MeSH
- Child MeSH
- Adult MeSH
- Immunohistochemistry MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Antibodies, Monoclonal MeSH
- Soft Tissue Neoplasms metabolism MeSH
- Neoplasms metabolism MeSH
- ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism MeSH
- Child, Preschool MeSH
- Flow Cytometry MeSH
- Recurrence MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Monoclonal MeSH
- ATP Binding Cassette Transporter, Subfamily B, Member 1 MeSH
Resistance to chemotherapy significantly affects the treatment results in various cancers. Multidrug resistance caused by P-glycoprotein expression is now widely studied in human malignancies. We present the results of P-glycoprotein expression examination in 91 tumor tissue samples obtained from children treated for different malignant tumors in the Dept. of Pediatric Oncology, Prague. The correlation between the level of P-glycoprotein expression and tumor histology, clinical outcome, use of therapy, relapse rate and metastatic disease was made. P-glycoprotein expression was found significantly more frequent in soft tissue sarcomas, neuroblastomas, and hepatoblastomas, and generally in disseminated disease. On the contrary, a high expression of P-glycoprotein was not found in malignant brain tumors and nephroblastomas. The data strongly support the possibility that the percentage of P-glycoprotein expressing cells in selected tumors (soft tissue sarcomas, neuroblastomas), may have a clinical importance.
DNA and histone deacetylases as targets for neuroblastoma treatment
