SKIP is an indispensable factor for Caenorhabditis elegans development
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12084813
PubMed Central
PMC123127
DOI
10.1073/pnas.112213799
PII: 112213799
Knihovny.cz E-resources
- MeSH
- Caenorhabditis elegans genetics growth & development MeSH
- RNA, Fungal antagonists & inhibitors genetics MeSH
- Animals, Genetically Modified MeSH
- Genes, Helminth MeSH
- Nuclear Proteins genetics physiology MeSH
- Ubiquitin-Protein Ligase Complexes MeSH
- Larva growth & development MeSH
- Caenorhabditis elegans Proteins genetics physiology MeSH
- Helminth Proteins genetics physiology MeSH
- RNA Polymerase II antagonists & inhibitors MeSH
- Transcription Factors genetics physiology MeSH
- Gene Expression Regulation, Developmental MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- bir-1 protein, C elegans MeSH Browser
- RNA, Fungal MeSH
- Nuclear Proteins MeSH
- Ubiquitin-Protein Ligase Complexes MeSH
- Caenorhabditis elegans Proteins MeSH
- Helminth Proteins MeSH
- RNA Polymerase II MeSH
- skp-1 protein, C elegans MeSH Browser
- Transcription Factors MeSH
SKI-binding protein (SKIP) is a transcription cofactor present in all eukaryotes. Here we show that SKIP is a unique protein that is required for Caenorhabditis elegans viability and development. Expression of CeSKIP (skp-1) assayed by RT-PCR and by GFP fluorescence in transgenic lines starts in embryos and continues to adulthood. Loss of CeSKIP activity by RNA-mediated inhibition results in early embryonic arrest similar to that seen following inhibition of RNA polymerase II. RNA polymerase II phosphorylation appears normal early in CeSKIP RNA-mediated inhibition treated embryos although the expression of several embryonic GFP reporter genes is severely restricted or absent. Our data suggest that CeSKIP is an essential component of many RNA polymerase II transcription complexes and is indispensable for C. elegans development.
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BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development
