Chromosomal aberrations in peripheral lymphocytes of children as biomarkers of environmental exposure and life style
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12191864
DOI
10.1016/s0378-4274(02)00166-2
PII: S0378427402001662
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation MeSH
- Biomarkers MeSH
- Chromosome Aberrations * MeSH
- Cytogenetic Analysis MeSH
- Child MeSH
- Adult MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Lymphocytes chemistry drug effects immunology MeSH
- Adolescent MeSH
- Environmental Monitoring methods MeSH
- Child, Preschool MeSH
- Metals, Heavy analysis MeSH
- Environmental Exposure adverse effects analysis MeSH
- Life Style * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Biomarkers MeSH
- Metals, Heavy MeSH
The original purpose of our study was to determine if the detection of chromosomal aberrations in peripheral lymphocytes of children might be used as a biomarker of environmental pollution and life style. We compared the results of cytogenetic analyses performed in children and adolescents in the periods 1984-1993 and 1994-1999, in a total of 3402 subjects. The frequency of aberrant cells (AB.C.) markedly decreased in the period 1994-1999 compared with the period 1984-1993. The decreases in AB.C. were significant in the age groups 7-15 and 16-19 years: 1.63% AB.C. versus 1.14% AB.C. and 2.02% AB.C. versus 1.08% AB.C., respectively (P<0.01). No difference in the frequency of AB.C. was observed in newborns. Based on our experience, we believe that monitoring the spontaneous level of chromosomal aberrations in children over 5 year periods may be used to examine the general changes in environmental pollution in larger geographic areas.
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