Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12372672
DOI
10.1016/s0895-7061(02)02984-9
PII: S0895706102029849
Knihovny.cz E-zdroje
- MeSH
- 5-methyltetrahydrofoláthomocystein-S-methyltransferasa genetika MeSH
- cystathionin-beta-synthasa genetika MeSH
- dospělí MeSH
- ferredoxin-NADP-reduktasa genetika MeSH
- genetická predispozice k nemoci epidemiologie MeSH
- homocystein metabolismus MeSH
- hypertenze epidemiologie genetika metabolismus MeSH
- inzulinová rezistence * MeSH
- kyselina listová metabolismus MeSH
- lidé MeSH
- methylentetrahydrofolátreduktasa (NADPH2) MeSH
- mladiství MeSH
- oxidoreduktasy působící na CH-NH vazby genetika MeSH
- polymorfismus genetický MeSH
- prevalence MeSH
- rizikové faktory MeSH
- vitamin B 12 metabolismus MeSH
- vitamin B6 metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 5-methyltetrahydrofoláthomocystein-S-methyltransferasa MeSH
- cystathionin-beta-synthasa MeSH
- ferredoxin-NADP-reduktasa MeSH
- homocystein MeSH
- kyselina listová MeSH
- methionine synthase reductase MeSH Prohlížeč
- methylentetrahydrofolátreduktasa (NADPH2) MeSH
- oxidoreduktasy působící na CH-NH vazby MeSH
- vitamin B 12 MeSH
- vitamin B6 MeSH
BACKGROUND: Although insulin resistance and elevated plasma homocysteine are associated with hypertension in adults, the role of these conditions in the initial phase of hypertension is largely unknown. We examined whether insulin resistance and disturbed homocysteine metabolism are present in young adults at the early stages of essential hypertension. METHODS: We measured physical characteristics, plasma levels of insulin, lipids, total homocysteine, and vitamins in 164 patients with essential juvenile hypertension (median age, 19 years; 92% males) and in 173 controls (median age, 18 years; 66% males). Furthermore, we analyzed the prevalence of six polymorphisms in four genes of the methionine cycle. RESULTS: Patients with hypertension and controls differed significantly (P <.05) in body mass index, levels of insulin, high-density lipoprotein-cholesterol, fasting and post-load plasma homocysteine, and folates. Systolic blood pressure was correlated with homocysteine levels and inversely correlated with plasma folates. Logistic regression showed that fasting homocysteine, vitamin B(12), and low-density lipoprotein-cholesterol were associated with a significantly increased risk of juvenile hypertension. In contrast, the birth length, polymorphism c.2756 A-->G in the MTR gene and plasma folate were associated with a significantly decreased risk of juvenile hypertension. CONCLUSIONS: Our study showed that essential hypertension in adolescents is associated with lower folate and higher homocysteine levels, and with signs of insulin resistance. These data suggest that hypertension in young individuals may be a part of early manifestation of insulin resistance syndrome, and that disturbed folate and homocysteine metabolism may play a role in the early stages of hypertension.
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