Essential role of AT1A receptor in the development of 2K1C hypertension
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Angiotensin Receptor Antagonists MeSH
- Imidazoles pharmacology MeSH
- Enzyme Inhibitors pharmacology MeSH
- Blood Pressure drug effects physiology MeSH
- Kidney pathology MeSH
- Disease Models, Animal MeSH
- Myocardium pathology MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Disease Progression MeSH
- Pyridines pharmacology MeSH
- Receptor, Angiotensin, Type 1 MeSH
- Receptor, Angiotensin, Type 2 MeSH
- Receptors, Angiotensin deficiency genetics metabolism MeSH
- Hypertension, Renovascular physiopathology MeSH
- Nitric Oxide Synthase antagonists & inhibitors MeSH
- Body Weight MeSH
- Organ Size MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Angiotensin Receptor Antagonists MeSH
- Imidazoles MeSH
- Enzyme Inhibitors MeSH
- PD 123319 MeSH Browser
- Pyridines MeSH
- Receptor, Angiotensin, Type 1 MeSH
- Receptor, Angiotensin, Type 2 MeSH
- Receptors, Angiotensin MeSH
- Nitric Oxide Synthase MeSH
The aims of this study were to delineate the relative contribution of angiotensin II (ANG II) subtype 1A (AT1A) and 1B (AT1B) receptors to the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in mice, to examine if increased nitric oxide synthase (NOS) activity counteracts the vasoconstrictor influences of ANG II in 2K1C hypertensive mice, and to determine the role of ANG II type 2 (AT2) receptors in 2K1C hypertension in mice. AT(1A) ANG II receptor knockout (AT1A-/-) and wild-type (AT1A+/+) mice underwent clipping of the right renal artery. Systolic blood pressure (SBP) was significantly lower in AT1A-/- compared with AT1A+/+ mice, and neither clip placement nor AT2 receptor blockade with PD 123319 (PD) altered SBP in AT1A-/- mice. A significant and sustained rise in SBP from 119+/-5 to 163+/-6 mm Hg was observed in the 2K1C AT1A+/+ mice from day 10 to day 26. Chronic PD infusion did not alter the course of hypertension in 2K1C/AT1A+/+. Acute PD infusion did not alter mean arterial pressure (MAP) in AT1A+/+, PD/AT1A+/+, 2K1C/AT1A+/+, PD/2K1C/AT1A+/+, AT1A-/-, PD/AT1A-/-, and PD/2K1C/AT1A-/- mice compared with basal levels. In contrast, acute PD infusion caused significant increases in MAP in 2K1C/AT1A-/- mice. The subsequent acute NOS inhibition caused greater increases in MAP in 2K1C/AT1A+/+ and PD/2K1C/AT1A+/+ mice than in AT1A+/+ and PD/AT1A+/+ mice. These results support the essential role of AT1A receptors in mediating 2K1C hypertension and support the hypothesis that augmented NO production serves as a counteracting system in this model of hypertension.
References provided by Crossref.org
Research on Experimental Hypertension in Prague (1966-2009)
