Gliadin, endomysial and thyroid antibodies in patients with latent autoimmune diabetes of adults (LADA)
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
12823288
PubMed Central
PMC1808742
DOI
10.1046/j.1365-2249.2003.02205.x
PII: 2205
Knihovny.cz E-resources
- MeSH
- Autoantibodies analysis MeSH
- Diabetes Mellitus, Type 1 immunology MeSH
- Diabetes Mellitus, Type 2 immunology MeSH
- Diabetes Mellitus immunology MeSH
- Gliadin immunology MeSH
- Immunoglobulin A immunology MeSH
- Immunoglobulin G immunology MeSH
- Iodide Peroxidase immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Antibodies, Anti-Idiotypic analysis MeSH
- Chi-Square Distribution MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Thyroglobulin immunology MeSH
- Age of Onset MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Autoantibodies MeSH
- Gliadin MeSH
- Immunoglobulin A MeSH
- Immunoglobulin G MeSH
- Iodide Peroxidase MeSH
- Antibodies, Anti-Idiotypic MeSH
- Thyroglobulin MeSH
Latent autoimmune diabetes of adults (LADA) manifested after the age of 35 is characterized by the presence of disease-specific autoantibodies (anti-glutamate decarboxylase GADAb, anti-IA2Ab). However, autoimmunity in Type 1 diabetes mellitus is not targeted only to pancreatic beta-cells. No data have so far been published concerning the antibodies associated with other autoimmune disease in LADA patients. The presence of anti-thyroglobulin (TGAb), anti-thyroid peroxidase (TPOAb), anti-gliadin IgA (AGAAb) and IgG (AGGAb) and endomysial antibodies (EMAb) in sera of 68 diabetics typed as LADA was compared with the antibody presence in sera of 85 patients with Type 2 diabetes. We found a significantly higher occurrence of gliadin antibodies in LADA patients: the rate of AGGAb was 19.1% in comparison with 3.5% in the T2DM group (P = 0.0026), the rate of AGAAb was 13.2% in comparison with 3.5% (P = 0.035). The prevalence of EMAb was very low in both groups (1.5% and 0). The two groups differed significantly in the TPOAb rate: 22.1% in LADA compared to 9.4% in T2DM (P = 0.04), whereas no significant difference was found in the presence of TGAb (8.8% and 3.5%, P = 0.187). In comparison with T2DM patients, LADA patients were found to express higher antibody activity against gluten-related antigens and against TPO.
See more in PubMed
Wucherpfennig KW, Eisenbarth GS. Type 1 diabetes. Nat Immunol. 2001;9:767–8. PubMed
Lohman T, Kellner K, Verlohren HL, et al. Titer and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adult (LADA) Diabetologia. 2001;44:1005–10. PubMed
Esteban LM, Baxter AG. Polyspecificity of autoimmune responses in Type 1 (autoimmune) diabetes. Clin Exp Immunol. 2001;126:184–6. PubMed PMC
Sigurs N, Johansson C, Elfstrand PO, et al. Prevalence of coeliac disease in diabetic children and adolescents in Sweden. Acta Paediatr. 1993;82:748–51. PubMed
Ascher H, Hahn-Zoric M, Hanson LA, Kilander AF, Nilsson LA, Tlaskalova H. Value of serologic markers for clinical diagnosis and population studies of coeliac disease. Scand J Gastroenterol. 1996;31:61–7. PubMed
Tučková L, Karská K, Walters JRF, et al. Anti-gliadin antibodies in patients with coeliac disease cross-react with enterocytes and human calreticulin. Clin Immunol Immunopathol. 1997;85:289–96. PubMed
Cataldo F, Ventura A, Lazzar R, et al. Antiendomysium antibodies and coeliac disease: solved and unsolved question. An Italian multicenter study. Acta Paediatr. 1995;84:1125–31. PubMed
Calero P, Ribes-Koninck C, Albiach V, et al. IgA anti-gliadin antibodies as a screening method for nonovert coeliac disease in children with insulin-dependent diabetes mellitus. J Pediatr Gastroenterol Nutr. 1996;23:29–33. PubMed
Fernandez-Castaner M, Molina A, Lopez-Jimenez L, et al. Clinical presentation and early course of type 1 diabetes in patients with and without thyroid autoimmunity. Diabetes Care. 1999;22:377–81. PubMed
Weetman AP. Determinants of autoimmune thyroid disease. Nat Immunol. 2001;2:769–70. PubMed
Gambelunghe G, Forini F, Laureti S, et al. Increased risk for endocrine autoimmunity in Italian Type 2 diabetic patients with GAD65 autoantibodies. Clin Endocrinol. 2000;52:565–73. PubMed
De Block CE, de Leeuw IH, Vertommen JJ, et al. Beta-cell, thyroid, gastric adrenal and coeliac autoimmunity and HLA-DQ types in Type 1 diabetes. Clin Exp Immunol. 2001;126:236–41. PubMed PMC
Silverberg AB, Mooradian AD. The thyroid and aging. In: Mobbs CV, Hof PR, editors. Functional endocrinology of aging. Basel: Karger; 1998. pp. 27–43.
Kaufman DL, Clare-Salzer M, Tian J, et al. Spontaneous loss of T cell tolerance to GAD in murine insulin dependents diabetes. Nature. 1993;366:69–72. PubMed PMC
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2001;24(Suppl.):S5–S20. PubMed
Not T, Citta A, Lucchesi A, et al. Anti-endomysium antibody on human umbilical cord vein tissue: an inexpensive and sensitive diagnostic tool for the screening of coeliac disease. Eur J Pediatr. 1997;156:616–8. PubMed
Lorini R, Scotta MS, Avanzini M, et al. IgA antibodies to gliadin, reticulin and reticulin for coeliac disease screening in children with insulin-dependent diabetes mellitus. J Pediatr. 1994;124:994–6. PubMed
Verge CF, Howard NJ, Rowley MJ, et al. Anti-glutamate decarboxylase and her antibodies at the onset of childhood IDDM, a population based study. Diabetologia. 1994;37:1113–20. PubMed
Martin-Villsa JM, Lopez Suarez JC, Perez Blas M, et al. Coeliac- and entheropathy-associated autoantibodies in Spanish insulin-dependent diabetes mellitus patients and their relation to HLA antigens. J Diabetes Compl. 2001;15:38–43. PubMed
Schaber E, Granditsch G. IDDM and coeliac disease. Diabetes Care. 1994;17:1549–55. PubMed
Kapuscinska A, Zalewski T, Chorzelski TP. Disease specificity and dynamics of changes in IgA class anti-endomysial antibodies in coeliac diseases. J Pediatr Gastroenterol Nutr. 1987;6:529–34. PubMed
Ashabani A, Abushofa A, Abusrewill S, Abdelazez M, Tučková L, Tlaskalová-Hogenová H. The prevalence of coeliac disease in Libyan children with insulin-dependent diabetes mellitus. Diabetes/Metab Res Rev. 2003;19:69–75. PubMed
Gillet PNM, Gilletz HR, Israel DM, et al. High prevalence of coeliac disease in patients with Type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. Can J Gastroenterol. 2000;5:297–301. PubMed
Cavell B, Stenhammar L, Ascher H, et al. Increasing incidence of childhood coeliac diseases in Sweden: results of a national study. Acta Pediatr. 1992;81:589–92. PubMed
Vančíková Z, Chlumecký V, Sokol D, et al. The serologic screening for coeliac disease in the general population (blood donors) and in some high-risk groups of adults (patients with autoimmune diseases, osteoporosis and infertility) in the Czech Republic − preliminary report. Folia Microbiol. 2002;47:753–8. PubMed
Kolb H, Pozzilli P. Cow's milk and type 1 diabetes: the gut immune system deserves attention. Immunol Today. 1999;20:108–10. PubMed
Harrison LC, Honeyman MC. Cow's milk and Type 1 diabetes. The real debate is about mucosal immune function. Diabetes. 1999;48:1501–7. PubMed
Weiner HL. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today. 1997;18:335–43. PubMed
Funda DP, Kaas A, Bock T, Tlaskalová-Hogenová H, Buschard K. Gluten-free diet prevents diabetes in NOD mice. Diabetes/Metab Res Rev. 1999;15:323–7. PubMed
Paronen J, Klemetti P, Kantele JM, et al. Glutamate decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut-specific homing receptor a4b-integrin. Diabetes. 1977;46:583–8. PubMed
Hanninen A, Salmi M, Simell O, et al. Mucosa-associated (beta7-integrin high) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior. Diabetes. 1996;45:1173–80. PubMed
Savilahti E, Ormala T, Sukkonen T, et al. Jejuna of patients with insulin-dependent diabetes mellitus show signs of immune activation. Clin Exp Immunol. 1999;116:70–7. PubMed PMC
De Block CE, de Leeuw IH, van Gaal L, et al. High prevalence of manifestation of gastric autoimmunity in parietal cell antibody-positive Type 1 (insulin dependent) diabetic patients. J Clin Endocrinol Metab. 1999;84:4062–7. PubMed