The role of relaxation time corrections for the evaluation of long and short echo time 1H MR spectra of the hippocampus by NUMARIS and LCModel techniques
Language English Country Germany Media print-electronic
Document type Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Validation Study
- MeSH
- Algorithms * MeSH
- Models, Biological * MeSH
- Choline metabolism MeSH
- Diagnosis, Computer-Assisted methods MeSH
- Adult MeSH
- Epilepsy, Temporal Lobe diagnosis metabolism MeSH
- Hippocampus metabolism MeSH
- Image Interpretation, Computer-Assisted MeSH
- Creatine metabolism MeSH
- Aspartic Acid analogs & derivatives metabolism MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy methods MeSH
- Magnetic Resonance Imaging methods MeSH
- Brain Mapping methods MeSH
- Nerve Tissue Proteins metabolism MeSH
- Protons MeSH
- Reproducibility of Results MeSH
- Sensitivity and Specificity MeSH
- Subtraction Technique MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Comparative Study MeSH
- Validation Study MeSH
- Names of Substances
- Choline MeSH
- Creatine MeSH
- Aspartic Acid MeSH
- N-acetylaspartate MeSH Browser
- Nerve Tissue Proteins MeSH
- Protons MeSH
1H MR spectroscopy is routinely used for lateralization of epileptogenic lesions. The present study deals with the role of relaxation time corrections for the quantitative evaluation of long (TE=135 ms) and short echo time (TE=10 ms) 1H MR spectra of the hippocampus using two methods (operator-guided NUMARIS and LCModel programs). Spectra of left and right hippocampi of 14 volunteers and 14 patients with epilepsy were obtained by PRESS (TR/TE=5000/135 ms) and STEAM (TR/TE=5000/10 ms) sequences with a 1.5-T imager. Evaluation was carried out using Siemens NUMARIS software and the results were compared with data from LCModel processing software. No significant differences between the two methods of processing spectra with TE=135 ms were found. The range of relaxation corrections was determined. Metabolite concentrations in hippocampi calculated from spectra with TE=135 ms and 10 ms after application of correction coefficients did not differ in the range of errors and agreed with published data (135 ms/10 ms: NAA=10.2+/-0.6/10.4+/-1.3 mM, Cho=2.4+/-0.1/2.7+/-0.3 mM, Cr=12.2+/-1.3/11.3+/-1.3 mM). When relaxation time corrections were applied, quantitative results from short and long echo time evaluation with LCModel were in agreement. Signal intensity ratios obtained from long echo time spectra by NUMARIS operator-guided processing also agreed with the LCModel results.
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