Plasma ghrelin levels and malnutrition: a comparison of two etiologies
Language English Country Germany Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
14649784
DOI
10.1007/bf03325015
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Ghrelin MeSH
- Nutrition Assessment MeSH
- Insulin-Like Growth Factor Binding Protein 3 blood MeSH
- Body Mass Index MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Leptin blood MeSH
- Receptors, Leptin MeSH
- Middle Aged MeSH
- Humans MeSH
- Anorexia Nervosa complications MeSH
- Fasting MeSH
- Peptide Hormones blood metabolism physiology MeSH
- Malnutrition blood diagnosis etiology MeSH
- Sex Characteristics MeSH
- Insulin-Like Growth Factor Binding Protein 1 blood MeSH
- Receptors, Cell Surface blood MeSH
- Growth Hormone blood MeSH
- Body Composition MeSH
- Case-Control Studies MeSH
- Short Bowel Syndrome complications MeSH
- Skinfold Thickness MeSH
- Adipose Tissue MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Ghrelin MeSH
- Insulin-Like Growth Factor Binding Protein 3 MeSH
- Insulin-Like Growth Factor I MeSH
- Leptin MeSH
- Receptors, Leptin MeSH
- Peptide Hormones MeSH
- Insulin-Like Growth Factor Binding Protein 1 MeSH
- Receptors, Cell Surface MeSH
- Growth Hormone MeSH
Ghrelin is a peptide hormone that is involved in regulating growth hormone secretion as well as food intake and energy homeostasis. The aim of this study was to compare changes in plasma ghrelin levels in patients with malnutrition due to anorexia nervosa (AN) or short bowel syndrome (SBS). Blood samples for laboratory analyses were taken from 16 AN patients (plus 13 comparable healthy controls) and 27 SBS patients (plus 13 comparable healthy controls) after an overnight fast. In comparison with their respective control groups, plasma ghrelin levels were increased in the AN patients (p < 0.05) and significantly decreased in the patients with SBS (p < 0.01). These results suggest that quantitative ghrelin secretion in the gut wall is important in determining ghrelin concentrations in the systemic circulation.
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