Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats
Language English Country Netherlands Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15177299
DOI
10.1016/j.phrs.2003.12.013
PII: S1043661803004237
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Phenols isolation & purification pharmacology MeSH
- Phytotherapy * MeSH
- Glucose administration & dosage adverse effects MeSH
- Glutathione Peroxidase drug effects metabolism MeSH
- Hypertriglyceridemia drug therapy genetics MeSH
- Liver chemistry drug effects metabolism MeSH
- Dietary Sucrose administration & dosage adverse effects antagonists & inhibitors MeSH
- Rats MeSH
- Thiobarbituric Acid Reactive Substances metabolism MeSH
- Lipoproteins, HDL blood drug effects MeSH
- Lipoproteins, LDL blood drug effects MeSH
- Disease Models, Animal MeSH
- Oxidative Stress drug effects physiology MeSH
- Lipid Peroxidation drug effects MeSH
- Rats, Wistar MeSH
- Prunella chemistry MeSH
- Plant Extracts chemistry isolation & purification pharmacology MeSH
- Silymarin chemistry isolation & purification pharmacology MeSH
- Superoxide Dismutase drug effects metabolism MeSH
- Cholesterol, VLDL blood drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Phenols MeSH
- Glucose MeSH
- Glutathione Peroxidase MeSH
- Dietary Sucrose MeSH
- Thiobarbituric Acid Reactive Substances MeSH
- Lipoproteins, HDL MeSH
- Lipoproteins, LDL MeSH
- Plant Extracts MeSH
- Silymarin MeSH
- Superoxide Dismutase MeSH
- Cholesterol, VLDL MeSH
The study tested the effects of phenolics-rich extracts from the plants Silybum marianum (silymarin) and Prunella vulgaris (PVE) on blood and liver antioxidant status and lipoprotein metabolism. Hereditary hypertriglyceridemic rats fed on standard diet (STD) or high-sucrose diet (HSD, 70cal% of sucrose) for two weeks were used. HSD doubled plasma and liver triacylglycerol (TAG) and increased plasma VLDL-TAG and VLDL-cholesterol compared to STD. Administration of silymarin or PVE as 1% dietary supplements in HSD did not influence lipid levels in plasma or liver, but both extracts caused decrease in plasma VLDL-cholesterol levels. HSD-induced oxidative stress was manifested in increased TBARS and conjugated dienes (CD) content, decreased GSH levels and glutathione peroxidase (GPX) activity in blood and liver. In blood the activity of superoxide dismutase (SOD) decreased, whereas in liver the activity of catalase increased after HSD. Feeding on HSD containing phenolics-rich extracts resulted in reduction of TBARS and CD content and in increase of blood GPX activity and elevated GSH content in liver. Besides, silymarin increased the activity of SOD and level of GSH in blood. Catalase activity in blood or liver was not influenced by the presence of plant extracts in the diet. These results indicate that silymarin and PVE improve antioxidant status in blood and liver and positively affect plasma lipoprotein profile in an experimental model of dietary induced hypertriglyceridemia.
References provided by Crossref.org
The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat
