Lung cancer risk among Czech tin and uranium miners--comparison of lifetime detriment
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15254655
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Tin MeSH
- Radon Daughters MeSH
- Adult MeSH
- Mining * MeSH
- Carcinogens, Environmental MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Lung Neoplasms epidemiology etiology MeSH
- Neoplasms, Radiation-Induced epidemiology MeSH
- Occupational Diseases * MeSH
- Occupational Exposure * MeSH
- Air Pollutants, Radioactive MeSH
- Air Pollution, Radioactive MeSH
- Radon MeSH
- Risk MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Uranium MeSH
- Age Factors MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Tin MeSH
- Radon Daughters MeSH
- Carcinogens, Environmental MeSH
- Air Pollutants, Radioactive MeSH
- Radon MeSH
- Uranium MeSH
First epidemiological evidence of lung cancer risk from exposure to radon was based on studies of uranium miners. The risk in other mines was reported later. The cohort study among 2466 Czech tin miners was conducted in order to estimate the size of the risk and to compare it to that in uranium mines. Based on 205 lung cancers, the estimate of excess relative risk per unit exposure in the simple linear model 0.011 is compatible with findings from two cohort studies of Czech uranium miners. This similarity holds in more complex models that include modifying effects of age and time since exposure. In addition, an alternative description of the risk in terms of lifetime risk was used. This approach provides summarized characteristics, in which modifying effects of time and age are incorporated. The attributive risk derived from the lifetime relative risk is proportional to cumulated exposure observed in both tin and uranium miners. On the other hand, the expected life shortening of 19 years among radiation induced deaths is similar in these studies.