Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15897309
PubMed Central
PMC1755507
DOI
10.1136/ard.2004.029140
PII: S0003-4967(24)42979-8
Knihovny.cz E-zdroje
- MeSH
- arginin analogy a deriváty analýza krev MeSH
- artróza kolenních kloubů krev diagnostické zobrazování metabolismus MeSH
- biologické markery analýza krev MeSH
- chrupavkový oligomerní matrixový protein MeSH
- extracelulární matrix - proteiny analýza MeSH
- glykoproteiny analýza MeSH
- kloubní chrupavka chemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lysin analogy a deriváty analýza krev MeSH
- matriliny MeSH
- průřezové studie MeSH
- radiografie MeSH
- senioři MeSH
- stupeň závažnosti nemoci MeSH
- synoviální tekutina chemie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- arginin MeSH
- biologické markery MeSH
- chrupavkový oligomerní matrixový protein MeSH
- extracelulární matrix - proteiny MeSH
- glykoproteiny MeSH
- lysin MeSH
- matriliny MeSH
- pentosidine MeSH Prohlížeč
- TSP5 protein, human MeSH Prohlížeč
BACKGROUND: Pentosidine, an advanced glycation end product, increasingly accumulates in articular cartilage with age, and contributes to the pathogenesis of osteoarthritis (OA). Increased pentosidine concentrations are associated with inflammatory disorders-for example, rheumatoid arthritis. OBJECTIVE: To compare pentosidine serum concentrations in patients with knee OA and in healthy volunteers and to determine a relationship between pentosidine and cartilage oligomeric matrix protein (COMP)-a marker of articular cartilage destruction. METHODS: Paired serum and synovial fluid samples were obtained by arthrocentesis from 38 patients with knee OA and from 38 healthy volunteers. Pentosidine concentration was measured by reverse phase high performance liquid chromatography with fluorescent detection and COMP was determined by sandwich ELISA. RESULTS: Significantly increased serum pentosidine (p<0.01) and COMP (p<0.05) levels were detected in the patients with OA compared with the control group. Serum pentosidine correlated significantly with synovial fluid pentosidine (p<0.001). Pentosidine in synovial fluid (p<0.05) and in serum (p<0.05) correlated significantly with synovial fluid COMP. Pentosidine and COMP concentrations did not correlate significantly with the radiological stage of the disease. CONCLUSION: Increased pentosidine serum concentration in patients with OA and its correlation with the cartilage destruction marker COMP in synovial fluid suggests that pentosidine may be important in OA pathology and is a new potential OA marker.
Zobrazit více v PubMed
Br J Rheumatol. 1998 Jul;37(7):721-8 PubMed
J Am Soc Nephrol. 1998 Sep;9(9):1681-8 PubMed
J Rheumatol. 1998 Dec;25(12):2440-4 PubMed
Arthritis Rheum. 1999 May;42(5):1003-9 PubMed
Rheumatology (Oxford). 1999 Dec;38(12):1275-8 PubMed
Biochem J. 2000 Sep 1;350 Pt 2:381-7 PubMed
Osteoarthritis Cartilage. 2000 Sep;8(5):335-42 PubMed
Rheum Dis Clin North Am. 2000 Aug;26(3):547-67 PubMed
J Orthop Res. 2001 Jan;19(1):33-42 PubMed
Arthritis Rheum. 2001 Nov;44(11):2562-71 PubMed
Osteoarthritis Cartilage. 2002 Jan;10(1):1-4 PubMed
Arthritis Rheum. 2002 Jan;46(1):114-23 PubMed
Cell Mol Life Sci. 2002 Jan;59(1):5-18 PubMed
Osteoarthritis Cartilage. 2002 Sep;10(9):707-13 PubMed
Rheumatology (Oxford). 2002 Sep;41(9):996-1000 PubMed
Clin Chim Acta. 2003 Feb;328(1-2):59-69 PubMed
Aging Clin Exp Res. 2003 Oct;15(5):364-72 PubMed
Ann Rheum Dis. 2004 Feb;63(2):200-5 PubMed
Osteoarthritis Cartilage. 2004 Apr;12(4):277-83 PubMed
Arthritis Rheum. 2004 Apr;50(4):1207-15 PubMed
Arthritis Rheum. 1986 Aug;29(8):1039-49 PubMed
J Biol Chem. 1989 Dec 25;264(36):21597-602 PubMed
Br J Rheumatol. 1992 Sep;31(9):583-91 PubMed
Arthritis Rheum. 1994 May;37(5):724-8 PubMed
Br J Rheumatol. 1995 Apr;34(4):306-10 PubMed
Osteoarthritis Cartilage. 1995 Sep;3 Suppl A:3-70 PubMed
Nephrol Dial Transplant. 1996;11 Suppl 5:27-30 PubMed
Arthritis Rheum. 1997 Apr;40(4):723-7 PubMed
Br J Rheumatol. 1997 Nov;36(11):1151-60 PubMed
Biochem Biophys Res Commun. 1998 Mar 6;244(1):45-9 PubMed
Arthritis Rheum. 1998 May;41(5):778-99 PubMed
